Evidence map›Paper›PMID 25627700›Full record

ArticlePediatric surgery international2015

Do infants with gastroschisis may have a high incidence of non-IgE-mediated cow's milk protein allergy?

David Burge, Melanie Drewett, Nigel Hall

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Article in Pediatric surgery international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
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1citing papers in PubMed
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1 · What the graph read from it

What it found

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David BurgeUniversity Hospital Southampton and University of Southampton, Southampton, UK, david.burge@uhs.nhs.uk.
Melanie Drewett
Nigel Hall

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background/purposeTo determine the frequency and characteristics of suspected cow's milk protein allergy (CMPA) in infants with gastroschisis and response to change in milk.

methodsA retrospective cohort study of 111 consecutive infants with gastroschisis.

results64 episodes suggesting non-IgE-mediated CMPA occurred in 50 infants (45 %) at a median age of 44 days (9-186) and during the primary admission in 38 %. At the time of the episode the infant feed was breast milk (BM, n = 24), term formula (TF, n = 20) or extensively hydrolysed formula (EHF, n = 6). The feed was changed to EHF (34), amino acid formula (AAF) (14) or BM with maternal CMP-free diet (2). Partial or complete resolution of symptoms occurred in all. There was histological evidence of an allergic reaction to CMP in all four infants in whom tissue was available. Recurrent episodes occurred in 13/50 infants (26 %), 10 of whom were receiving EHF. There were no recurrent episodes in infants being fed with AAF.

conclusionFeatures suggesting non-IgE-mediated CMPA appear common in infants with gastroschisis.

Indexed as

Breast FeedingCohort StudiesComorbidityFemaleGastroschisisHumansIncidenceInfantInfant FormulaInfant, NewbornMaleMilk HypersensitivityMilk ProteinsRetrospective StudiesMilk Proteins

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.