Evidence map›Paper›PMID 25627678›Full record

ArticleBMC health services research2015

How to improve prescription of inhaled salbutamol by providing standardised feedback on administration: a controlled intervention pilot study with follow-up.

Martina P Neininger, Almuth Kaune, Astrid Bertsche, Jessica Rink, Juliane Musiol, Roberto Frontini, Freerk Prenzel, Wieland Kiess, Thilo Bertsche

Open access · goldAbstract readComparative Study
In one paragraph

Article in BMC health services research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Martina P NeiningerDrug Safety Center, University of Leipzig, Leipzig, Germany. MartinaPatrizia.Neininger@medizin.uni-leipzig.de.
Almuth KauneDrug Safety Center, University of Leipzig, Leipzig, Germany. Almuth.Kaune@medizin.uni-leipzig.de.
Astrid BertscheDepartment of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research, University of Leipzig, Leipzig, Germany. Astrid.Bertsche@medizin.uni-leipzig.de.
Jessica RinkDrug Safety Center, University of Leipzig, Leipzig, Germany. jessica.rink@gmx.de.
Juliane MusiolDrug Safety Center, University of Leipzig, Leipzig, Germany. juliane_musiol@hotmail.de.
Roberto FrontiniDrug Safety Center, University of Leipzig, Leipzig, Germany. Roberto.Frontini@medizin.uni-leipzig.de.
Freerk PrenzelDepartment of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research, University of Leipzig, Leipzig, Germany. Freerk.Prenzel@medizin.uni-leipzig.de.
Wieland KiessDepartment of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research, University of Leipzig, Leipzig, Germany. Wieland.Kiess@medizin.uni-leipzig.de.
Thilo BertscheDrug Safety Center, University of Leipzig, Leipzig, Germany. thilo.bertsche@medizin.uni-leipzig.de.
Leipzig University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effectiveness of inhaled salbutamol in routine care depends particularly on prescribed dosage and applied inhalation technique. To achieve maximum effectiveness and to prevent drug-related problems, prescription and administration need to work in concert.

methodsWe performed a controlled intervention pilot study with 4 consecutive groups in a general paediatric unit and assessed problems in salbutamol prescribing and administration. Control group [i]: Routine care without additional support. First intervention group [ii]: We carried out a teaching session for nurses aimed at preventing problems in inhalation technique. Independently from this, a pharmacist counselled physicians on problems in salbutamol prescribing. Second intervention group [iii]: Additionally to the first intervention, physicians received standardised feedback on the inhalation technique. Follow-up group [iv]: Subsequently, without any delay after the second intervention group had been completed, sustainability of the measures was assessed. We performed the chi-square test to calculate the level of significance with p ≤ 0.05 to indicate a statistically significant difference for the primary outcome. As we performed multiple testing, an adjusted p ≤ 0.01 according to Bonferroni correction was considered as significant.

resultsWe included a total of 225 patients. By counselling the physicians, we reduced the number of patients with problems from 55% to 43% (control [i] vs. first intervention [ii], n.s.). With additional feedback to physicians, this number was further reduced to 25% ([i] vs. [iii], p < 0.001). In the follow-up [iv], the number rose again to 48% (p < 0.01 compared to feedback group).

conclusionsTeaching nurses, counselling physicians, and providing feedback on the quality of inhalation technique effectively reduced problems in salbutamol treatment. However, for success to be sustained, continuous support needs to be provided.

trial registrationGerman Clinical Trials register: DRKS00006792 .

Indexed as

Administration, InhalationAdolescentAdultAlbuterolAsthmaBronchodilator AgentsChildChild, PreschoolFemaleFollow-Up StudiesGermanyHumansInfantMaleMiddle AgedNursing Staff, HospitalAlbuterolBronchodilator Agents

Identifiers

PMID25627678
PMCPMC4314799
OpenAlexW2031044103

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.