ArticleJournal of neural engineering2015
Stability and selectivity of a chronic, multi-contact cuff electrode for sensory stimulation in human amputees.
Article in Journal of neural engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it, 175 citations in OpenAlex.
- Artificial referred sensation in upper and lower limb prosthesis users: a systematic review.Journal of neural engineering · 2022Pooled it
- First-in-human implementation of a bidirectional somatosensory neuroprosthetic system with wireless communication.Journal of neuroengineering and rehabilitation · 2025Trial
- Selective neural electrical stimulation restores hand and forearm movements in individuals with complete tetraplegia.Journal of neuroengineering and rehabilitation · 2020Trial
- Characterization of multi-channel intraneural stimulation in transradial amputees.Scientific reports · 2019Trial
- Sensory feedback by peripheral nerve stimulation improves task performance in individuals with upper limb loss using a myoelectric prosthesis.Journal of neural engineering · 2016Trial
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- Coordinated hand movement sensation revealed through an implanted magnetic prosthetic kinesthetic interface.Science advances · 2026Article
- Automated 3D segmentation of human vagus nerve fascicles and epineurium from micro-computed tomography images using anatomy-aware neural networks.Journal of neural engineering · 2026Article
- Restoring hand grasping for patients with a complete tetraplegia with selective epineural stimulation: a parsimonious thus relevant clinical approach.Journal of neuroengineering and rehabilitation · 2026Article
- Enhanced sensory perception and myoelectric control with high channel count implanted sensorimotor systems.Journal of neural engineering · 2025Article
- Investigating the Feasibility and Safety of Osseointegration With Neural Interfaces for Advanced Prosthetic Control.Cureus · 2025Review
- The Next Frontier in Neuroprosthetics: Integration of Biomimetic Somatosensory Feedback.Biomimetics (Basel, Switzerland) · 2025Review
- Clinical Applications and Future Translation of Somatosensory Neuroprostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Phantom limb syndrome: from pathogenesis to treatment. A narrative review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Creation of a biological sensorimotor interface for bionic reconstruction.Nature communications · 2024Article
- Reconnecting the Hand and Arm to the Brain: Efficacy of Neural Interfaces for Sensorimotor Restoration After Tetraplegia.Neurosurgery · 2024Article
- Neuromorphic hardware for somatosensory neuroprostheses.Nature communications · 2024Review
- Selective chronic recording in small nerve fascicles of sciatic nerve with carbon nanotube yarns in rats.Journal of neural engineering · 2024Article
- Cortical Reorganization after Limb Loss: Bridging the Gap between Basic Science and Clinical Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Time series classification of multi-channel nerve cuff recordings using deep learning.PloS one · 2024Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveStability and selectivity are important when restoring long-term, functional sensory feedback in individuals with limb-loss. Our objective is to demonstrate a chronic, clinical neural stimulation system for providing selective sensory response in two upper-limb amputees. APPROACH: Multi-contact cuff electrodes were implanted in the median, ulnar, and radial nerves of the upper-limb. MAIN
resultsNerve stimulation produced a selective sensory response on 19 of 20 contacts and 16 of 16 contacts in subjects 1 and 2, respectively. Stimulation elicited multiple, distinct percept areas on the phantom and residual limb. Consistent threshold, impedance, and percept areas have demonstrated that the neural interface is stable for the duration of this on-going, chronic study. SIGNIFICANCE: We have achieved selective nerve response from multi-contact cuff electrodes by demonstrating characteristic percept areas and thresholds for each contact. Selective sensory response remains consistent in two upper-limb amputees for 1 and 2 years, the longest multi-contact sensory feedback system to date. Our approach demonstrates selectivity and stability can be achieved through an extraneural interface, which can provide sensory feedback to amputees.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.