ArticleJournal of medical microbiology2015
Clonal diversity of CTX-M-producing, multidrug-resistant Escherichia coli from rodents.
Article in Journal of medical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Antimicrobial resistance of Escherichia coli in Hungarian wild rats and characterization of a CTX-M-1 type ESBL plasmid.Scientific reports · 2026Article
- Decoding Mastitis in Small Rodent Pets: Pathophysiology, Antimicrobial Resistance Profiles, and Future Directions in Treatment Strategies.Antibiotics (Basel, Switzerland) · 2025Review
- Extended Spectrum Beta-Lactamase Producing Escherichia coli in Pet Cats and Dogs in Central Peninsular Malaysia.Veterinary medicine and science · 2025Article
- Comparative Genomic Analyses ofJournal of microbiology and biotechnology · 2024Article
- Synanthropic rodents and shrews are reservoirs of zoonotic bacterial pathogens and act as sentinels for antimicrobial resistance spillover in the environment: A study from Puducherry, India.One health (Amsterdam, Netherlands) · 2024Article
- Current epidemiologic features and health dynamics of ESBL-producingBiosafety and health · 2024Review
- Antimicrobial resistance in bacteria isolated from peridomesticOne health (Amsterdam, Netherlands) · 2023Article
- A global overview of the most important zoonotic bacteria pathogens transmitted fromInfectious medicine · 2022Review
- High Prevalence of Beta-Lactam-ResistantMicroorganisms · 2022Article
- Article
- Characterization of beta-lactam-resistantMicrobial genomics · 2021Article
- Association between theAntibiotics (Basel, Switzerland) · 2021Article
- Occurrence and Antimicrobial Resistance Traits ofInternational journal of environmental research and public health · 2020Article
- Antibiotic-resistant Escherichia coli isolated from urban rodents in Hanoi, Vietnam.The Journal of veterinary medical science · 2020Article
- A metagenomic glimpse into the gut of wild and domestic animals: Quantification of antimicrobial resistance and more.PloS one · 2020Article
- Article
- Urban brown rats (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Porcine commensal Escherichia coli: a reservoir for class 1 integrons associated with IS26.Microbial genomics · 2017Article
- The role of wildlife (wild birds) in the global transmission of antimicrobial resistance genes.Zoological research · 2017Review
Corrections and comments
- Erratum issuedErratum.2015
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This territory-wide study investigated the occurrence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli among wild rodents from the 18 districts in Hong Kong. Individual rectal swabs were obtained from the trapped animals and cultured in plain and selective media. A total of 965 wild rodents [148 chestnut spiny rats (Niviventer fulvescens), 326 Indo-Chinese forest rats (Rattus andamanensis), 452 brown rats (Rattus norvegicus) and 39 black rats (Rattus rattus)] were sampled. ESBL carriage was 0 % in chestnut spiny rats, 0.6 % in Indo-Chinese forest rats, 7.7 % in black rats and 13.9 % in brown rats. Among brown rats, the prevalence of ESBL carriage differed markedly by geographical location: absent in two districts, low (7-10 %) in six districts, moderate (11-19 %) in seven districts and high (21-50 %) in three districts. Nonetheless, there was no correlation between the prevalence of ESBL in brown rats and human population density in the 18 districts. CTX-M-type enzymes were detected in 92.0 % of the ESBL-producing isolates, of which 83.1 % were resistant to three or more non-β-lactam drugs. The CTX-M producing isolates were genetically diverse but a large proportion (47.8 %) were included in six successful clones that are strongly associated with human diseases and CTX-M dissemination, viz. sequence type complex [STC]10/phylogroup A, STC23/phylogroup B1, STC38/phylogroup D, STC155/phylogroup B1, ST405/phylogroup D and ST131/phylogroup B2. In conclusion, our results show that brown rats often carry potentially zoonotic clones of CTX-M producing, multidrug-resistant E. coli. The potential for rats to be a source of CTX-M producing E. coli for humans deserves further consideration.
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