ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2015
Type III collagen modulates fracture callus bone formation and early remodeling.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Expression of collagen type III and tenascin-C during joint formation in embryonic chick skull.Anatomical science international · 2026Article
- Bioglass-Reinforced Spongin-Like Collagen Scaffolds for Osteoporotic Bone Tissue Engineering.ACS omega · 2026Article
- Cow's Milk Positively Impacts Bone Formation by Regulating the Osteocalcin Pathway Compared to Transgenic and Non-Transgenic Soy-Based Beverages in BALB/c Mice.Molecular nutrition & food research · 2026Article
- Physicochemical Characterization, Cytotoxicity, and In Vivo Evaluation of a Hydroxyapatite-Silver Composite for Bone Regeneration.BioMed research international · 2026Article
- Applications of recombinant type III collagen in tissue engineering.Biomedical engineering online · 2025Review
- Type III Collagen Regulates Matrix Architecture and Mechanosensing during Wound Healing.The Journal of investigative dermatology · 2025Article
- Development and Characterization of PEGylated Poly D,L-Lactic Acid Nanoparticles for Skin Rejuvenation.Nanomaterials (Basel, Switzerland) · 2025Article
- Jinkui Shenqi Pill accelerates osteoporotic fracture healing by promoting bone formation through neurosensory PGE2/EP4/p-CREB axis.Frontiers in endocrinology · 2025Article
- Prognostic and therapeutic implications of tumor-restrictive type III collagen in the breast cancer microenvironment.NPJ breast cancer · 2024Article
- Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration.Nature communications · 2024Article
- Transcriptional Profiling of Muscle in Females With Distal Radius Fracture and Functional Sarcopenia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- The effects of cephalexin on fracture healing in a rat femur fracture model.Joint diseases and related surgery · 2023Article
- Human epidermal keratinocytes and human dermal fibroblasts interactions seeded on gelatin hydrogel for future application in skinFrontiers in bioengineering and biotechnology · 2023Article
- Spheroid co-culture of BMSCs with osteocytes yields ring-shaped bone-like tissue that enhances alveolar bone regeneration.Scientific reports · 2022Article
- Cysteine-rich domain of type III collagen N-propeptide inhibits fibroblast activation by attenuating TGFβ signaling.Matrix biology : journal of the International Society for Matrix Biology · 2022Article
- Review
- Systemic Administration of Recombinant Irisin Accelerates Fracture Healing in Mice.International journal of molecular sciences · 2021Article
- Canine Mesenchymal Stromal Cell-Mediated Bone Regeneration is Enhanced in the Presence of Sub-Therapeutic Concentrations of BMP-2 in a Murine Calvarial Defect Model.Frontiers in bioengineering and biotechnology · 2021Article
- Animal Models of Ehlers-Danlos Syndromes: Phenotype, Pathogenesis, and Translational Potential.Frontiers in genetics · 2021Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Type III collagen (Col3) has been proposed to play a key role in tissue repair based upon its temporospatial expression during the healing process of many tissues, including bone. Given our previous finding that Col3 regulates the quality of cutaneous repair, as well as our recent data supporting its role in regulating osteoblast differentiation and trabecular bone quantity, we hypothesized that mice with diminished Col3 expression would exhibit altered long-bone fracture healing. To determine the role of Col3 in bone repair, young adult wild-type (Col3+/+) and haploinsufficent (Col3+/-) mice underwent bilateral tibial fractures. Healing was assessed 7, 14, 21, and 28 days following fracture utilizing microcomputed tomography (microCT), immunohistochemistry, and histomorphometry. MicroCT analysis revealed a small but significant increase in bone volume fraction in Col3+/- mice at day 21. However, histological analysis revealed that Col3+/- mice have less bone within the callus at days 21 and 28, which is consistent with the established role for Col3 in osteogenesis. Finally, a reduction in fracture callus osteoclastic activity in Col3+/- mice suggests Col3 also modulates callus remodeling. Although Col3 haploinsufficiency affected biological aspects of bone repair, it did not affect the regain of mechanical function in the young mice that were evaluated in this study. These findings provide evidence for a modulatory role for Col3 in fracture repair and support further investigations into its role in impaired bone healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.