ArticleEnvironmental microbiology2015
The bacterial alarmone (p)ppGpp is required for virulence and controls cell size and survival of Pseudomonas syringae on plants.
Article in Environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- A global stress alarmone couples nutrient limitation to suppression of social signaling in bacteria.iScience · 2026Article
- Shared Microbial Blueprints Underlying Symbiotic Plasticity in Desert Plant Endophytes.Microorganisms · 2026Article
- Bacterial alarmone (p)ppGpp mediates the pathogenicity ofmSystems · 2025Article
- Tale of Twin Bifunctional Second Messenger (p)ppGpp Synthetases and Their Function in Mycobacteria.ACS omega · 2023Review
- Elicitor-induced plant immunity relies on amino acids accumulation to delay the onset of bacterial virulence.Plant physiology · 2023Article
- Termination factor Rho mediates transcriptional reprogramming of Bacillus subtilis stationary phase.PLoS genetics · 2023Article
- The Importance of Microorganisms for Sustainable Agriculture-A Review.Metabolites · 2022Review
- MAMP-elicited changes in amino acid transport activity contribute to restricting bacterial growth.Plant physiology · 2022Article
- Virulence-related regulatory network ofComputational and structural biotechnology journal · 2022Review
- The Role of RelA and SpoT on ppGpp Production, Stress Response, Growth Regulation, and Pathogenicity in Xanthomonas campestris pv.Microbiology spectrum · 2021Article
- Many birds with one stone: targeting the (p)ppGpp signaling pathway of bacteria to improve antimicrobial therapy.Biophysical reviews · 2021Review
- The extended (p)ppGpp family: New dimensions in Stress response.Current research in microbial sciences · 2021Review
- Extraction and detection of guanosine 5'-diphosphate-3'-diphosphate in amino acid starvation cells of Clavibacter michiganensis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Regulation of theMicroorganisms · 2021Review
- Innovation and Application of the Type III Secretion System Inhibitors in Plant Pathogenic Bacteria.Microorganisms · 2020Review
- Characterization of RelA in Acinetobacter baumannii.Journal of bacteriology · 2020Article
- Comparative transcriptomic analysis of global gene expression mediated by (p) ppGpp reveals common regulatory networks in Pseudomonas syringae.BMC genomics · 2020Article
- The stringent response regulator (p) ppGpp mediates virulence gene expression and survival in Erwinia amylovora.BMC genomics · 2020Article
- Signal transduction schemes inComputational and structural biotechnology journal · 2020Review
- Stringent response regulators (p)ppGpp and DksA positively regulate virulence and host adaptation of Xanthomonas citri.Molecular plant pathology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
The stringent response, mediated by second messenger (p)ppGpp, results in swift and massive transcriptional reprogramming under nutrient limited conditions. In this study, the role of (p)ppGpp on virulence of Pseudomonas syringae pv. syringae B728a (PssB728a) was investigated. The virulence of the relA/spoT (ppGpp(0) ) double mutant was completely impaired on bean, and bacterial growth was significantly reduced, suggesting that (p)ppGpp is required for full virulence of P. syringae. Expression of T3SS and other virulence genes was reduced in ppGpp(0) mutants. In addition, ppGpp deficiency resulted in loss of swarming motility, reduction of pyoverdine production, increased sensitivity to oxidative stress and antibiotic tolerance, as well as reduced ability to utilize γ-amino butyric acid. Increased levels of ppGpp resulted in reduced cell size of PssB728a when grown in a minimal medium and on plant surfaces, while most ppGpp(0) mutant cells were not viable on plant surfaces 24 h after spray inoculation, suggesting that ppGpp-mediated stringent response temporarily limits cell growth, and might control cell survival on plants by limiting their growth. These results demonstrated that ppGpp-mediated stringent response plays a central role in P. syringae virulence and survival and indicated that ppGpp serves as a global signal for regulating various virulence traits in PssB728a.
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Registered trials
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