ArticlePhysiological reports2015
Age related vascular endothelial function following lifelong sedentariness: positive impact of cardiovascular conditioning without further improvement following low frequency high intensity interval training.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-Term Aerobic Exercise Improves Vascular Function Into Old Age: A Systematic Review, Meta-Analysis and Meta Regression of Observational and Interventional Studies.Frontiers in physiology · 2019Pooled it
- Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation.Physiological reports · 2017Trial
- Trial
- Vascular-endothelial adaptations following low and high volumes of high-intensity interval training in patients after myocardial infarction.Therapeutic advances in cardiovascular diseaseTrial
- The impact of age and exercise training on endothelial-mediated mechanisms of vasodilation during passive leg movement in males.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Low-frequency resistance training enhances 2D strain-derived carotid strain and strain rate: a novel longitudinal application of strain imaging in healthy middle-aged females.European journal of applied physiology · 2026Article
- Effects of regular exercise on vascular function with aging: Does sex matter?American journal of physiology. Heart and circulatory physiology · 2024Review
- The effect of exercise on blood concentrations of angiogenesis markers in older adults: a systematic review and meta-analysis.Research square · 2023Article
- VascuFit: vascular effects of non-linear periodized exercise training in sedentary adults with elevated cardiovascular risk - protocol for a randomized controlled trial.BMC cardiovascular disorders · 2022Article
- Short-Term and Lifelong Exercise Training Lowers Inflammatory Mediators in Older Men.Frontiers in physiology · 2021Article
- Evidence-Based, High-Intensity Exercise and Physical Activity for Compressing Morbidity in Older Adults: A Narrative Review.Innovation in aging · 2019Article
- Cardiac Response to Exercise in Normal Ageing: What Can We Learn from Masters Athletes?Current cardiology reviews · 2018Review
- Exercise training improves free testosterone in lifelong sedentary aging men.Endocrine connections · 2017Article
- Short-term exercise training improves flow-mediated dilation and circulating angiogenic cell number in older sedentary adults.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is associated with diffuse impairments in vascular endothelial function and traditional aerobic exercise is known to ameliorate these changes. High intensity interval training (HIIT) is effective at improving vascular function in aging men with existing disease, but its effectiveness remains to be demonstrated in otherwise healthy sedentary aging. However, the frequency of commonly used HIIT protocols may be poorly tolerated in older cohorts. Therefore, the present study investigated the effectiveness of lower frequency HIIT (LfHIIT) on vascular function in a cohort of lifelong sedentary (SED; n = 22, age 62.7 ± 5.2 years) men compared with a positive control group of lifelong exercisers (LEX; n = 17, age 61.1 ± 5.4 years). The study consisted of three assessment phases; enrolment to the study (Phase A), following 6 weeks of conditioning exercise in SED (Phase B) and following 6 weeks of low frequency HIIT in both SED and LEX (LfHIIT; Phase C). Conditioning exercise improved FMD in SED (3.4 ± 1.5% to 4.9 ± 1.1%; P < 0.01) such that the difference between groups on enrolment (3.4 ± 1.5% vs. 5.3 ± 1.4%; P < 0.01) was abrogated. This was maintained but not further improved following LfHIIT in SED whilst FMD remained unaffected by LfHIIT in LEX. In conclusion, LfHIIT is effective at maintaining improvements in vascular function achieved during conditioning exercise in SED. LfHIIT is a well-tolerated and effective exercise mode for reducing cardiovascular risk and maintaining but does not improve vascular function beyond that achieved by conditioning exercise in aging men, irrespective of fitness level.
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