ArticleJournal of oral microbiology2014
The oral microbiota of patients with recurrent aphthous stomatitis.
Article in Journal of oral microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Oral mucosal microbiome alterations in recurrent aphthous stomatitis: a systematic review of 16 S rRNA gene sequencing studies.Molecular biology reports · 2026Pooled it
- Salivary proteomics suggests persistent inflammatory signatures after clinical healing in recurrent aphthous stomatitis: a hypothesis-generating case-control study.BMC oral health · 2026Article
- Association between red biofluorescence and microbial dysbiosis in cariogenic biofilms: an in vitro study.Scientific reports · 2026Article
- Prevalence and Risk Factors of Aphthous Ulcers Following Periodontal Surgery: A Cross-Sectional Analysis.Journal of clinical medicine · 2026Article
- Analysis of Oral Microbiota in Herpetiform Aphthous Ulcers Patients.Oral health & preventive dentistry · 2025Article
- Aphthous stomatitis - computational biology suggests external biotic stimulus and immunogenic cell death involved.BMC oral health · 2024Article
- Nationwide exploration: assessing oral microbiome knowledge among dental professionals in Saudi Arabia and its implications for oral health care.BMC oral health · 2024Article
- Classification-Predictive Model Based on Artificial Neural Network Validated by Histopathology and Direct Immunofluorescence for the Diagnosis of Oral Lichen Planus.Diagnostics (Basel, Switzerland) · 2024Article
- Article
- Natural and Synthetic Drugs Approached for the Treatment of Recurrent Aphthous Stomatitis Over the Last Decade.Drug design, development and therapy · 2024Review
- Metataxonomic and metaproteomic profiling of the oral microbiome in oral lichen planus - a pilot study.Journal of oral microbiology · 2023Article
- Efficacy of Topical Intervention for Recurrent Aphthous Stomatitis: A Network Meta-Analysis.Medicina (Kaunas, Lithuania) · 2022Review
- Recurrent Aphthous Stomatitis Affects Quality of Life. A Case-Control Study.Clinical, cosmetic and investigational dentistry · 2022Article
- Detection and Analysis of the Oral Flora in Patients with Recurrent Aphthous Stomatitis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Oral Aphthous: Pathophysiology, Clinical Aspects and Medical Treatment.Archives of Razi Institute · 2021Review
- Salivary proteome of aphthous stomatitis reveals the participation of vitamin metabolism, nutrients, and bacteria.Scientific reports · 2021Article
- Comparison of microbiomes in ulcerative and normal mucosa of recurrent aphthous stomatitis (RAS)-affected patients.BMC oral health · 2020Article
- A Clinic Trial Evaluating the Effects of Aloe Vera Fermentation Gel on Recurrent Aphthous Stomatitis.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2020Article
- Low-Level Laser Therapy and Topical Medications for Treating Aphthous Ulcers: A Systematic Review.Journal of multidisciplinary healthcare · 2020Review
- Penicillin in oral aphthosis, new insight for an old drug: A randomized, double-blind, controlled clinical trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpecific pathogenic bacteria have been implicated in recurrent aphthous stomatitis (RAS), a chronic inflammatory condition characterised by ulcerations in the oral mucosa. However, the aetiology behind this condition still remains unclear.
objectiveThe buccal microbiota of patients with RAS was compared to that of control subjects to investigate its potential role for this condition.
designBuccal swabs were obtained from non-ulcerative areas of 60 patients, of whom 42 patients had lesions at the time of sampling, and 60 healthy age- and gender-matched controls. Bacterial DNA was extracted and analysed by Terminal-Restriction Fragment Length Polymorphism, using enzymatic digestion of the polymerase chain reaction-amplified 16S rRNA gene, yielding a series of peaks, each representing a bacterial taxon.
resultsTwo peaks, 60 and 489, were more prevalent in patients with RAS than controls. Conversely, peaks 58 and 490 were less common in patients than controls. When the patients were divided into subgroups, we found that the observed differences in peak-pattern were related to the presence of lesions during sampling.
conclusionsThe microbiota of the non-inflamed buccal mucosa differed between patients and controls. The differences were most pronounced in patients who presented with lesions during sampling, suggesting that a disturbance in the normal buccal microbiota triggers the presence of lesions or that presence of lesions alters the microbiota.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.