SynthesisMolecular nutrition & food research2015
Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Molecular nutrition & food research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
6.6field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Interactions between genetic and lifestyle factors on cardiometabolic disease-related outcomes in Latin American and Caribbean populations: A systematic review.Frontiers in nutrition · 2023Pooled it
- n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies.Diabetes care · 2021Pooled it
- Genome-wide meta-analyses identify novel loci associated with n-3 and n-6 polyunsaturated fatty acid levels in Chinese and European-ancestry populations.Human molecular genetics · 2016Pooled it
- Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.The American journal of clinical nutrition · 2016Pooled it
- Trial
- Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention.Nutrients · 2017Trial
- Erythrocyte linoleic acid, but not oleic acid, is associated with improvements in body composition in men and women.Molecular nutrition & food research · 2016Trial
- Decomposed interaction testing improves detection of genetic modifiers of the relationship of dietary omega-3 fatty acid intake and its plasma biomarkers with hsCRP in the UK Biobank.Genes & nutrition · 2025Article
- Polyunsaturated Fatty Acids and Human Health: A Key to Modern Nutritional Balance in Association with Polyphenolic Compounds from Food Sources.Foods (Basel, Switzerland) · 2024Review
- Decomposed interaction testing improves detection of genetic modifiers of the relationship of dietary omega-3 fatty acid intake and its plasma biomarkers with hsCRP in the UK Biobank.medRxiv : the preprint server for health sciences · 2024Article
- Serum fatty acid profiles in systemic lupus erythematosus and patient reported outcomes: The Michigan Lupus Epidemiology & Surveillance (MILES) Program.Frontiers in immunology · 2024Article
- Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness.European heart journal open · 2022Article
- Association of dietaryFrontiers in nutrition · 2022Article
- Erythrocyte Long-Chain ω-3 Fatty Acids Are Positively Associated with Lean Mass and Grip Strength in Women with Recent Diagnoses of Breast Cancer.The Journal of nutrition · 2021Article
- Ancestry specific associations of a genetic risk score, dietary patterns and metabolic syndrome: a longitudinal ARIC study.BMC medical genomics · 2021Article
- Genetic study of the Arctic CPT1A variant suggests that its effect on fatty acid levels is modulated by traditional Inuit diet.European journal of human genetics : EJHG · 2020Article
- Seafood, fatty acid biosynthesis genes, and multiple sclerosis susceptibility.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Article
- The combined effects of FADS gene variation and dietary fats in obesity-related traits in a population from the far north of Sweden: the GLACIER Study.International journal of obesity (2005) · 2019Article
- Genes and Dietary Fatty Acids in Regulation of Fatty Acid Composition of Plasma and Erythrocyte Membranes.Nutrients · 2018Review
- Sex Differences in Omega-3 and -6 Fatty Acids and Health Status Among Young Adults With Acute Myocardial Infarction: Results From the VIRGO Study.Journal of the American Heart Association · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 19 institutions in 5 countries.
Caren E SmithNutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA*
Jack L FollisDepartment of Mathematics, Computer Science, and Cooperative Engineering, University of St. Thomas, Houston, TX, USA.
Jennifer A NettletonDivision of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
Millennia FoyInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Jason H Y WuThe George Institute for Global Health, The University of Sydney, Sydney, NSW, Australia.
Yiyi MaNutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA*
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Ani W ManichakulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Hongyu WuDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Audrey Y ChuDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Lyn M SteffenDivision of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
Myriam FornageDivision of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
Dariush MozaffarianDepartment of Epidemiology, Harvard School of Public Health, Harvard Medical School, Boston, MA, USA.
Edmond K KabagambeDivision of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN, USA.
Luigi FerruciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Yii-Der Ida ChenInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor, UCLA Medical Center, Torrance, CA, USA.
Stephen S RichDivision of Biostatistics and Epidemiology, University of Virginia, Charlottesville, VA, USA.
Luc DjousséDivision of Aging, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Weihong TangDivision of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
Barbara McKnightDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Michael Y TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Stefania BandinelliGeriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Florence, Italy.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor, UCLA Medical Center, Torrance, CA, USA.
Frank B HuDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
Donna K ArnettDepartment of Epidemiology, Section on Statistical Genetics, and The Office of Energetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Irena B KingDepartment of Internal Medicine, Division of Endocrinology, University of New Mexico, Albuquerque, NM, USA.
Qi SunDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Lu WangDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Thomas LumleyDepartment of Statistics, University of Auckland, Auckland, New Zealand.
Stephanie E ChiuveDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
David S SiscovickCardiovascular Health Research Unit, Department of Medicine, Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
José M OrdovásNutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA*
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
Brigham and Women's Hospital · USKaiser Permanente Washington Health Research Institute · USThe University of Texas Health Science Center at Houston · USTufts University · USHarbor–UCLA Medical Center · USHarvard University · USMinnesota Department of Health · USNational Institute on Aging · USUniversity of Virginia · USAzienda Sanitaria di Firenze · ITEnergetics (United States) · USUniversity of Auckland · NZUniversity of Minnesota · USUniversity of New Mexico · USUniversity of St. Thomas - Texas · USUniversity of Sydney · AUUniversity of Washington · USVA Boston Healthcare System · USVanderbilt University · US
Funding
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MHarvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MA Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MRISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8MDietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6MIntramural NIH HHSNCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCATS NIH HHS UL1 TR000170NCI NIH HHS CA047988NCI NIH HHS CA055075NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA87969NCI NIH HHS R01 CA047988NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA182913NCRR NIH HHS RR-024156NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01-HG-004424NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01-HG-004446NHGRI NIH HHS U01 HG004729NHGRI NIH HHS U01-HG-004729NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS HL078885NHLBI NIH HHS HL080295NHLBI NIH HHS HL080467NHLBI NIH HHS HL085710NHLBI NIH HHS HL087652NHLBI NIH HHS HL099355NHLBI NIH HHS HL105756NHLBI NIH HHS HL54776NHLBI NIH HHS HL60712NHLBI NIH HHS K08 HL112845NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R00 HL095649NHLBI NIH HHS R00-HL095649NHLBI NIH HHS R00 HL097068NHLBI NIH HHS R00 HL098459NHLBI NIH HHS R00HL098459NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL035464NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL054776NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL060712NHLBI NIH HHS R01 HL078885NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL084099NHLBI NIH HHS R01-HL-084099NHLBI NIH HHS R01 HL085710NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL091357NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL35464NHLBI NIH HHS R01HL59367NHLBI NIH HHS RC1 HL099355NHLBI NIH HHS U01 HL072524NHLBI NIH HHS U01HL072524NHLBI NIH HHS U01 HL080295NIA NIH HHS AG023629NIA NIH HHS R01 AG023629NIA NIH HHS R56 AG023629NIDDK NIH HHS DK063491NIDDK NIH HHS P30 DK063491NIMHD NIH HHS R01 MD009164
Abstract
scopeTissue concentrations of omega-3 fatty acids may reduce cardiovascular disease risk, and genetic variants are associated with circulating fatty acids concentrations. Whether dietary fatty acids interact with genetic variants to modify circulating omega-3 fatty acids is unclear. We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha-linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid. METHODS AND
resultsWe conducted meta-analyses (N = 11 668) evaluating interactions between dietary fatty acids and genetic variants (rs174538 and rs174548 in FADS1 (fatty acid desaturase 1), rs7435 in AGPAT3 (1-acyl-sn-glycerol-3-phosphate), rs4985167 in PDXDC1 (pyridoxal-dependent decarboxylase domain-containing 1), rs780094 in GCKR (glucokinase regulatory protein), and rs3734398 in ELOVL2 (fatty acid elongase 2)). Stratification by measurement compartment (plasma versus erthyrocyte) revealed compartment-specific interactions between FADS1 rs174538 and rs174548 and dietary alpha-linolenic acid and linoleic acid for docosahexaenoic acid and docosapentaenoic acid.
conclusionOur findings reinforce earlier reports that genetically based differences in circulating fatty acids may be partially due to differences in the conversion of fatty acid precursors. Further, fatty acids measurement compartment may modify gene-diet relationships, and considering compartment may improve the detection of gene-fatty acids interactions for circulating fatty acid outcomes.
Indexed as
DietAcetyltransferasesAcyltransferasesAdaptor Proteins, Signal TransducingCarboxy-LyasesDelta-5 Fatty Acid DesaturaseDocosahexaenoic AcidsEicosapentaenoic AcidErythrocyte MembraneFatty Acid DesaturasesFatty Acid ElongasesFatty AcidsFatty Acids, Omega-3FemaleHumansMale2-acylglycerophosphate acyltransferaseAcetyltransferasesAcyltransferasesAdaptor Proteins, Signal TransducingCarboxy-LyasesDelta-5 Fatty Acid DesaturaseDocosahexaenoic AcidsEicosapentaenoic AcidELOVL2 protein, humanFADS1 protein, humanFatty Acid DesaturasesFatty Acid ElongasesFatty AcidsFatty Acids, Omega-3GCKR protein, humanPDXDC1 protein, humanFADS1Gene-diet interactionsMeta-analysisOmega-3 fatty acids
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