ArticleDocumenta ophthalmologica. Advances in ophthalmology2015
Electrophysiological and microperimetry changes in vitamin A deficiency retinopathy.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Vitamin A deficiency retinopathy in the setting of celiac disease and liver fibrosis.Documenta ophthalmologica. Advances in ophthalmology · 2024Article
- The Value of Electroretinography in Identifying Candidate Genes for Inherited Retinal Dystrophies: A Diagnostic Guide.Diagnostics (Basel, Switzerland) · 2023Review
- Vitamin A deficiency and the retinal "double carrot" sign with optical coherence tomography.Eye (London, England) · 2023Article
- The Role of Vitamin A in Retinal Diseases.International journal of molecular sciences · 2022Review
- Visual electrophysiology in the assessment of toxicity and deficiency states affecting the visual system.Eye (London, England) · 2021Review
- Treatment of vitamin A deficiency retinopathy with sublingual vitamin A palmitate.Documenta ophthalmologica. Advances in ophthalmology · 2016Review
- Recurrent episodes of night blindness in a patient with short bowel syndrome.Documenta ophthalmologica. Advances in ophthalmology · 2015Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe a follow-up case of vitamin A deficiency (VAD)-related retinopathy with macular involvement monitored with electroretinography and microperimetry.
methodsFlash (ERG), pattern (PERG), and multifocal (mfERG) electroretinography were recorded in parallel with microperimetry before and during 7-month follow-up of vitamin A treatment on a 65-year-old man presented with a 1-year history of night blindness. The patient had undergone ileostomy procedure for Crohn's disease 14 years ago. His best corrected visual acuity was 6/6 in each eye. Fundus examination revealed macular and mid-peripheral yellow-white lesions compatible with drusen.
resultsBefore treatment, PERG was reduced, and mfERG was reduced and delayed, worse in responses from the central rings. These results revealed evidence of bilateral macular and central cone dysfunction. The flash ERG showed reduced dark-adapted 0.01 ERG (rod response); a-wave of dark-adapted 3.0 and 10.0 ERG was normal but b-wave was reduced (negative configuration); light-adapted 3.0 ERG was slightly reduced. The flash ERG revealed evidence of bilateral generalised retinal dysfunction affecting the rod more than cone system. Microperimetry showed deep reduction in retinal sensitivity. Fixation stability was unstable with eccentric locus. During treatment, ERG and microperimetry demonstrated significant improvements. Fixation stability reached normal values after the third treatment week.
conclusionsThis case illustrates the importance of electrophysiological investigation in early VAD-related retinopathy detection correlated with microperimetry. Our findings indicate a more delayed central cone function recovery than that of generalised rod and cone function. There was a marked correlation between ERG and microperimetric changes.
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