ArticleEnvironmental health perspectives2015
Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris).
Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Effects of prenatal exposure to NOEnvironmental science and pollution research international · 2020Pooled it
- Effect of Air Pollution on the Basal DNA Damage of Mother-Newborn Couples of México City.Toxics · 2023Article
- Recovery and reactivity of polycyclic aromatic hydrocarbons collected on selected sorbent tubes and analyzed by thermal desorption-gas chromatography/mass spectrometry.Journal of chromatography. A · 2019Article
- Children as Biomarker Orphans: Progress in the Field of Pediatric Biomarkers.The Journal of pediatrics · 2018Article
- Neonicotinoid insecticide residues in surface water and soil associated with commercial maize (corn) fields in southwestern Ontario.PloS one · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
39 authors at 19 institutions in 11 countries.
Funding
Abstract
backgroundBulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk.
objectiveWe selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates.
methodsPregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006-2010. Cord blood bulky DNA adduct levels were measured by the 32P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population.
resultsGreek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 108 nucleotides, p < 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England.
conclusionThese findings suggest that a combination of factors, including unknown country-specific factors, influence the bulky DNA adduct levels in neonates.
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Registered trials
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