ArticlePLoS biology2015
Population diversification in a yeast metabolic program promotes anticipation of environmental shifts.
Article in PLoS biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons.Nucleic acids research · 2016Pooled it
- The type of carbon source not the growth rate it supports can determine diauxie in Saccharomyces cerevisiae.Communications biology · 2025Article
- A biological circuit to anticipate trend.Evolution letters · 2024Article
- Shaping of microbial phenotypes by trade-offs.Nature communications · 2024Review
- Biodiversity is enhanced by sequential resource utilization and environmental fluctuations via emergent temporal niches.PLoS computational biology · 2024Article
- Single-cell analysis of multiple invertible promoters reveals differential inversion rates as a strong determinant of bacterial population heterogeneity.Science advances · 2023Article
- Stochastic scanning events on the GCN4 mRNA 5' untranslated region generate cell-to-cell heterogeneity in the yeast nutritional stress response.Nucleic acids research · 2023Article
- Recognition of galactose by a scaffold protein recruits a transcriptional activator for theeLife · 2023Article
- Spatiotemporal Patterning Enabled by Gene Regulatory Networks.ACS omega · 2023Article
- Stringent response ensures the timely adaptation of bacterial growth to nutrient downshift.Nature communications · 2023Article
- Escherichia coli robustly expresses ATP synthase at growth rate-maximizing concentrations.The FEBS journal · 2022Article
- Diauxic lags explain unexpected coexistence in multi-resource environments.Molecular systems biology · 2022Article
- Polysaccharide utilization loci in Bacteroides determine population fitness and community-level interactions.Cell host & microbe · 2022Article
- Do microbes have a memory? History-dependent behavior in the adaptation to variable environments.Frontiers in microbiology · 2022Review
- Suboptimal resource allocation in changing environments constrains response and growth in bacteria.Molecular systems biology · 2021Article
- Computational analysis of GAL pathway pinpoints mechanisms underlying natural variation.PLoS computational biology · 2021Article
- Article
- Variation in the modality of a yeast signaling pathway is mediated by a single regulator.eLife · 2021Article
- Microbial metabolic noise.WIREs mechanisms of disease · 2021Review
- Gene Regulation and Cellular Metabolism: An Essential Partnership.Trends in genetics : TIG · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Delineating the strategies by which cells contend with combinatorial changing environments is crucial for understanding cellular regulatory organization. When presented with two carbon sources, microorganisms first consume the carbon substrate that supports the highest growth rate (e.g., glucose) and then switch to the secondary carbon source (e.g., galactose), a paradigm known as the Monod model. Sequential sugar utilization has been attributed to transcriptional repression of the secondary metabolic pathway, followed by activation of this pathway upon depletion of the preferred carbon source. In this work, we demonstrate that although Saccharomyces cerevisiae cells consume glucose before galactose, the galactose regulatory pathway is activated in a fraction of the cell population hours before glucose is fully consumed. This early activation reduces the time required for the population to transition between the two metabolic programs and provides a fitness advantage that might be crucial in competitive environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.