SynthesisEnvironmental health perspectives2015
Association of arsenic with adverse pregnancy outcomes/infant mortality: a systematic review and meta-analysis.
Synthesis in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 5 syntheses or guidelines pooled it, 349 citations in OpenAlex.
- Unsafe drinking water and human health: A global umbrella review of disease outcomes, intervention effectiveness, and policy implications.Cell reports. Medicine · 2026Pooled it
- Health Effects of Cyclones: A Systematic Review and Meta-Analysis of Epidemiological Studies.Environmental health perspectives · 2023Pooled it
- Towards Integrated Air Pollution Monitoring and Health Impact Assessment Using Federated Learning: A Systematic Review.Frontiers in public health · 2022Pooled it
- Positive Association of Cardiovascular Disease (CVD) with Chronic Exposure to Drinking Water Arsenic (As) at Concentrations below the WHO Provisional Guideline Value: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Inorganic arsenic and respiratory health, from early life exposure to sex-specific effects: A systematic review.Environmental research · 2016Pooled it
- Assessing preterm infant metal exposures in shed teeth: findings from the Developmental Impact of NICU Exposures (DINE) study.Journal of exposure science & environmental epidemiology · 2026Article
- Trace Element Dyshomeostasis as a Mediator of Toxic Metal-Induced Reproductive Dysfunction: Mechanistic Insights and Future Perspectives.Biological trace element research · 2026Review
- Toxic Trace Element Levels in Maternal and Cord Blood Worldwide and Their Impact on Pregnancy: A Narrative Review.Journal of xenobiotics · 2026Review
- Luminescent Naphthalenediimide-Tröger's Base Covalent Organic Polymers for Selective, Sensitive, and Reversible Detection of Roxarsone in Aqueous Media.Chemistry, an Asian journal · 2026Article
- Article
- Risk factors for neonatal mortality: an umbrella review of systematic reviews and meta-analyses.EClinicalMedicine · 2025Review
- Metformin Mitigates the Impact of Arsenic Exposure on the Maternal and Offspring Reproductive System of Female Mice.Biological trace element research · 2025Article
- Review
- Drinking water source and exposure to regulated water contaminants in the California Teachers Study cohort.Journal of exposure science & environmental epidemiology · 2025Article
- Assessing Heavy Metal Contamination in Food: Implications for Human Health and Environmental Safety.Toxics · 2025Review
- Overview of foodborne hazards associated with inflammation and metabolic health.BMC global and public health · 2025Review
- Biomonitoring and Health Risk Assessment of Arsenic Contamination in Drinking Water among Rural Residents in Western Tehran.PloS one · 2025Article
- Testing for heavy metals in drinking water collected from Dog Aging Project participants.PLOS water · 2025Article
- Risk factors of under-five and infant mortality: An umbrella review of systematic reviews and meta-analyses.Journal of global health · 2024Review
- Interplay Between Vitamin D Levels and Heavy Metals Exposure in Pregnancy and Childbirth: A Systematic Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to arsenic is one of the major global health problems, affecting > 300 million people worldwide, but arsenic's effects on human reproduction are uncertain.
objectivesWe conducted a systematic review and meta-analysis to examine the association between arsenic and adverse pregnancy outcomes/infant mortality.
methodsWe searched PubMed and Ovid MEDLINE (from 1946 through July 2013) and EMBASE (from 1988 through July 2013) databases and the reference lists of reviews and relevant articles. Studies satisfying our a priori eligibility criteria were evaluated independently by two authors.
resultsOur systematic search yielded 888 articles; of these, 23 were included in the systematic review. Sixteen provided sufficient data for our quantitative analysis. Arsenic in groundwater (≥ 50 μg/L) was associated with increased risk of spontaneous abortion (6 studies: OR = 1.98; 95% CI: 1.27, 3.10), stillbirth (9 studies: OR = 1.77; 95% CI: 1.32, 2.36), moderate risk of neonatal mortality (5 studies: OR = 1.51; 95% CI: 1.28, 1.78), and infant mortality (7 studies: OR = 1.35; 95% CI: 1.12, 1.62). Exposure to environmental arsenic was associated with a significant reduction in birth weight (4 studies: β = -53.2 g; 95% CI: -94.9, -11.4). There was paucity of evidence for low-to-moderate arsenic dose.
conclusionsArsenic is associated with adverse pregnancy outcomes and infant mortality. The interpretation of the causal association is hampered by methodological challenges and limited number of studies on dose response. Exposure to arsenic continues to be a major global health issue, and we therefore advocate for high-quality prospective studies that include individual-level data to quantify the impact of arsenic on adverse pregnancy outcomes/infant mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.