Evidence map›Paper›PMID 25625766›Full record

ArticleEmerging infectious diseases2015

Microbiota that affect risk for shigellosis in children in low-income countries.

Brianna Lindsay, Joe Oundo, M Anowar Hossain, Martin Antonio, Boubou Tamboura, Alan W Walker, Joseph N Paulson, Julian Parkhill, Richard Omore, Abu S G Faruque and 18 more

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Bacteriophage Therapy AgainstAntibiotics (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Temporal trends ofFrontiers in public health · 2026
    Observational
  5. Fecal microbiome profiling of children withMicrobiology spectrum · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Recent insights into Shigella.Current opinion in infectious diseases · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 10 institutions in 8 countries.

Brianna Lindsay
Joe Oundo
M Anowar Hossain
Martin Antonio
Boubou Tamboura
Alan W Walker
Joseph N Paulson
Julian Parkhill
Richard Omore
Abu S G Faruque
Suman Kumar Das
Usman N Ikumapayi
Mitchell Adeyemi
Doh Sanogo
Debasish Saha
Samba Sow
Tamer H Farag
Dilruba Nasrin
Shan Li
Sandra Panchalingam
Myron M Levine
Karen Kotloff
Laurence S Magder
Laura Hungerford
Halvor Sommerfelt
Mihai Pop
James P Nataro
O Colin Stine
University of Maryland, Baltimore · USMRC Unit the Gambia · GMCentre Pour le Développement des Vaccins-Mali · MLInternational Centre for Diarrhoeal Disease Research · BDKenya Medical Research Institute · KEUniversity of Maryland, College Park · USWellcome Sanger Institute · GBUniversity of Bergen · NOUniversity of Queensland · AUUniversity of Virginia · US

Funding

Severe Enteric Disease: Pathogenesis and ResponseU19AI090873 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BOWER, DONNA ADAMS · 2010 to 2014
$7.2M
Medical Research Council MC_U190074190Medical Research Council MC_U190081991NIAID NIH HHS U19 AI090873PHS HHS U19 090873
6 · The paper itself

Abstract

Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17-0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8-220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.-induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene.

Indexed as

MicrobiotaAge FactorsBiodiversityCase-Control StudiesChild, PreschoolDeveloping CountriesDiarrheaDysentery, BacillaryFecesGastrointestinal TractGenes, BacterialHumansInfantInfant, NewbornMetagenomeOdds RatioRNA, Ribosomal, 16S

Identifiers

PMID25625766
PMCPMC4313639
OpenAlexW2116593462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.