Evidence map›Paper›PMID 25625652›Full record

ArticleEnvironmental health perspectives2015

Prenatal air pollution exposure and newborn blood pressure.

Lenie van Rossem, Sheryl L Rifas-Shiman, Steven J Melly, Itai Kloog, Heike Luttmann-Gibson, Antonella Zanobetti, Brent A Coull, Joel D Schwartz, Murray A Mittleman, Emily Oken and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Pre- and postnatal exposure to PMEnvironmental research · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
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  10. Review
  11. Review
  12. Article
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  15. Article
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  18. Postnatal exposure to PMEnvironmental epidemiology (Philadelphia, Pa.) · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Lenie van RossemDepartment of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.
Sheryl L Rifas-Shiman
Steven J Melly
Itai Kloog
Heike Luttmann-Gibson
Antonella Zanobetti
Brent A Coull
Joel D Schwartz
Murray A Mittleman
Emily Oken
Matthew W Gillman
Petros Koutrakis
Diane R Gold
Harvard University · USBrigham and Women's Hospital · USBen-Gurion University of the Negev · ILBeth Israel Deaconess Medical Center · USUniversity Medical Center Utrecht · NL

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Effect of Ambient Particles on Acute Stroke OnsetP01ES009825 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI GOLD, DIANE R · 1999 to 2009
$17.4M
Pre- and Peri-natal Predictors of Childhood ObesityR37HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2012 to 2015
$4.5M
The Fetal and Childhood Environment, Oxidative Balance, Inflammation and AsthmaR01AI102960 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLD, DIANE R, OKEN, EMILY · 2013 to 2017
$4.0M
Patient-oriented Research in Maternal Perinatal Overnutrition and Child AdiposityK24HD069408 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2011 to 2015
$844k
NIAID NIH HHS R01 AI102960NICHD NIH HHS K24 HD069408NICHD NIH HHS R01 HD034568NICHD NIH HHS R37 HD034568NIEHS NIH HHS P01 ES009825NIEHS NIH HHS P30 ES000002
6 · The paper itself

Abstract

backgroundAir pollution exposure has been associated with increased blood pressure in adults.

objectiveWe examined associations of antenatal exposure to ambient air pollution with newborn systolic blood pressure (SBP).

methodsWe studied 1,131 mother-infant pairs in a Boston, Massachusetts, area pre-birth cohort. We calculated average exposures by trimester and during the 2 to 90 days before birth for temporally resolved fine particulate matter (≤ 2.5 μm; PM2.5), black carbon (BC), nitrogen oxides, nitrogen dioxide, ozone (O3), and carbon monoxide measured at stationary monitoring sites, and for spatiotemporally resolved estimates of PM2.5 and BC at the residence level. We measured SBP at a mean age of 30 ± 18 hr with an automated device. We used mixed-effects models to examine associations between air pollutant exposures and SBP, taking into account measurement circumstances; child's birth weight; mother's age, race/ethnicity, socioeconomic position, and third-trimester BP; and time trend. Estimates represent differences in SBP associated with an interquartile range (IQR) increase in each pollutant.

resultsHigher mean PM2.5 and BC exposures during the third trimester were associated with higher SBP (e.g., 1.0 mmHg; 95% CI: 0.1, 1.8 for a 0.32-μg/m3 increase in mean 90-day residential BC). In contrast, O3 was negatively associated with SBP (e.g., -2.3 mmHg; 95% CI: -4.4, -0.2 for a 13.5-ppb increase during the 90 days before birth).

conclusionsExposures to PM2.5 and BC in late pregnancy were positively associated with newborn SBP, whereas O3 was negatively associated with SBP. Longitudinal follow-up will enable us to assess the implications of these findings for health during later childhood and adulthood.

Indexed as

Blood PressureAir PollutantsAir PollutionBostonCarbon MonoxideCohort StudiesEnvironmental MonitoringFemaleHumansInfant, NewbornMaleMaternal ExposureNitrogen OxidesOzoneParticle SizeParticulate MatterAir PollutantsCarbon MonoxideNitrogen OxidesOzoneParticulate MatterSoot

Identifiers

PMID25625652
PMCPMC4384198
OpenAlexW2066448217

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.