ArticlePloS one2015
Preschool anxiety disorders predict different patterns of amygdala-prefrontal connectivity at school-age.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Predicting pediatric anxiety from the temporal pole using neural responses to emotional faces.Scientific reports · 2021Trial
- Identifying a structural brain network for social anxiety: connectome-based predictive modeling and network analyses in a transdiagnostic sample.Translational psychiatry · 2026Article
- Neurobiological correlates of personality dimensions in borderline personality disorder using graph analysis of functional connectivity.Scientific reports · 2025Article
- Experimental evidence for a child-to-adolescent switch in human amygdala-prefrontal cortex communication: A cross-sectional pilot study.Developmental science · 2022Article
- Age-related change in task-evoked amygdala-prefrontal circuitry: A multiverse approach with an accelerated longitudinal cohort aged 4-22 years.Human brain mapping · 2022Article
- ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.Human brain mapping · 2022Review
- Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group.Translational psychiatry · 2021Article
- Emerging Evidence for Putative Neural Networks and Antecedents of Pediatric Anxiety in the Fetal, Neonatal, and Infant Periods.Biological psychiatry · 2021Review
- Microstructure of the Dorsal Anterior Cingulum Bundle in Very Preterm Neonates Predicts the Preterm Behavioral Phenotype at 5 Years of Age.Biological psychiatry · 2021Article
- Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework.Progress in brain research · 2019Article
- Please Don't Leave Me-Separation Anxiety and Related Traits in Borderline Personality Disorder.Current psychiatry reports · 2018Review
- Protracted dendritic growth in the typically developing human amygdala and increased spine density in young ASD brains.The Journal of comparative neurology · 2018Article
- Discrimination of amygdala response predicts future separation anxiety in youth with early deprivation.Journal of child psychology and psychiatry, and allied disciplines · 2016Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveIn this prospective, longitudinal study of young children, we examined whether a history of preschool generalized anxiety, separation anxiety, and/or social phobia is associated with amygdala-prefrontal dysregulation at school-age. As an exploratory analysis, we investigated whether distinct anxiety disorders differ in the patterns of this amygdala-prefrontal dysregulation.
methodsParticipants were children taking part in a 5-year study of early childhood brain development and anxiety disorders. Preschool symptoms of generalized anxiety, separation anxiety, and social phobia were assessed with the Preschool Age Psychiatric Assessment (PAPA) in the first wave of the study when the children were between 2 and 5 years old. The PAPA was repeated at age 6. We conducted functional MRIs when the children were 5.5 to 9.5 year old to assess neural responses to viewing of angry and fearful faces.
resultsA history of preschool social phobia predicted less school-age functional connectivity between the amygdala and the ventral prefrontal cortices to angry faces. Preschool generalized anxiety predicted less functional connectivity between the amygdala and dorsal prefrontal cortices in response to fearful faces. Finally, a history of preschool separation anxiety predicted less school-age functional connectivity between the amygdala and the ventral prefrontal cortices to angry faces and greater school-age functional connectivity between the amygdala and dorsal prefrontal cortices to angry faces.
conclusionsOur results suggest that there are enduring neurobiological effects associated with a history of preschool anxiety, which occur over-and-above the effect of subsequent emotional symptoms. Our results also provide preliminary evidence for the neurobiological differentiation of specific preschool anxiety disorders.
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