Evidence map›Paper›PMID 25624776›Full record

ArticleClinical medicine insights. Arthritis and musculoskeletal disorders2015

Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial).

Seyed Ahmad Raeissadat, Seyed Mansoor Rayegani, Hossein Hassanabadi, Mohammad Fathi, Elham Ghorbani, Marzieh Babaee, Kamran Azma

5 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical medicine insights. Arthritis and musculoskeletal disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 148 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 23 pooled it
33.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03122119 phase4completednot on this mapstarted 2017, after this paper: background citation

Effectiveness of Ultrasound Guided Platelet Rich Plasma Injections in the Sacroiliac Joint to Relieve Low Back Pain

TypeinterventionalSponsorStar Spine and SportRan2017 to 2022Enrolled51ConditionsChronic Low Back Pain, Sacroiliitis, Sacroiliac, BackacheArmsPlatelet Rich Plasma Joint Injection
NCT03477630 phase3completednot on this mapstarted 2019, after this paper: background citation

Open Treatment for Pain and Inflammation in Knee Osteoarthrosis With Platelet-rich Plasma, Comparative Study With Hyaluronic Acid

TypeinterventionalSponsorKarla Andrea Arias VarelaRan2019 to 2020Enrolled28ConditionsOsteoarthritisArmsPlatelet Rich Plasma, Hyaluronic Acid
NCT05579665 phase1 / phase2completednot on this mapstarted 2022, after this paper: background citation

Comparative Effectiveness of Platelet Rich Plasma (PRP), Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell Culture (MSCs) Secretome and Hyaluronic Acid (HA) for the Treatment of Knee Osteoarthritis

TypeinterventionalSponsorUniversitas SriwijayaRan2022 to 2023Enrolled45ConditionsKnee OsteoarthritisArmsPlatelet-rich Plasma, Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell Culture (MSCs) Secretome, Low Molecular Weight Hyaluronic Acid
NCT06432842 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Knee Osteoarthritis and Lazer Therapy

TypeinterventionalSponsorKarabuk UniversityRan2023 to 2024Enrolled30ConditionsKnee OsteoarthritisArmsLaser Treatment
NCT06605560 nacompletednot on this mapstarted 2024, after this paper: background citation

Ultrasound-guided Baker Cyst Aspiration Combined With Platelet-rich Plasma Injection in Knee Osteoarthritis: a Randomised Clinical Trial

TypeinterventionalSponsorIzmir Katip Celebi UniversityRan2024 to 2025Enrolled32ConditionsPain, Quality of Life, Baker Cyst, Knee OsteoarthritisArmsPlatelet Rich Plasma
3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 23 syntheses or guidelines pooled it, 325 citations in OpenAlex.

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88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Seyed Ahmad RaeissadatPhysical Medicine and Rehabilitation Department, Clinical Development Center of Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed Mansoor RayeganiPhysical Medicine and Rehabilitation Department, PM & R Research Center of Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hossein HassanabadiPhysical Medicine and Rehabilitation Department, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad FathiAnesthesiology Department, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Elham GhorbaniPhysical Medicine and Rehabilitation Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Marzieh BabaeePhysical Medicine and Rehabilitation Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Kamran AzmaPhysical Medicine and Rehabilitation Department, AJA University of Medical Sciences, Tehran, Iran.
Shahid Beheshti University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionKnee osteoarthritis (OA) is the most common articular disease. Different methods are used to alleviate the symptoms of patients with knee OA, including analgesics, physical therapy, exercise prescription, and intra-articular injections (glucocorticoids, hyaluronic acid [HA], etc). New studies have focused on modern therapeutic methods that stimulate cartilage healing process and improve the damage, including the use of platelet-rich plasma (PRP) as a complex of growth factors. Due to the high incidence of OA and its consequences, we decided to study the long-term effect of intraarticular injection of PRP and HA on clinical outcome and quality of life of patients with knee OA.

methodThis non-placebo-controlled randomized clinical trial involved 160 patients affected by knee OA, grade 1-4 of Kellgren-Lawrence scale. In the PRP group (n = 87), two intra-articular injections at 4-week interval were applied, and in the HA group (n = 73), three doses of intra-articular injection at 1-week interval were applied. All patients were prospectively evaluated before and at 12 months after the treatment by Western Ontario and McMaster Universities Arthritis Index (WOMAC) and SF-36 questionnaires. The results were analyzed using SPSS 16.1 software (RCT code: IRCT2014012113442N5).

resultsAt the 12-month follow-up, WOMAC pain score and bodily pain significantly improved in both groups; however, better results were determined in the PRP group compared to the HA group (P < 0.001). Other WOMAC and SF-36 parameters improved only in the PRP group. More improvement (but not statistically significant) was achieved in patients with grade 2 OA in both the groups.

conclusionThis study suggests that PRP injection is more efficacious than HA injection in reducing symptoms and improving quality of life and is a therapeutic option in select patients with knee OA who have not responded to conventional treatment.

Indexed as

hyaluronic acidintra-articular injectionknee osteoarthritisplatelet-rich plasma

Identifiers

PMID25624776
PMCPMC4287055
OpenAlexW2088653124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.