Trial reportClinical interventions in aging2015
A pilot randomized controlled trial using EEG-based brain-computer interface training for a Chinese-speaking group of healthy elderly.
Trial report in Clinical interventions in aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04439591 (Group-based Brain-computer Interface), which is not on this map. Cited by 19 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Group-based Brain-computer Interface (BCI) Cognitive Training in Healthy Older Adults: An Evaluation of Programme Implementation and Effectiveness in Neighborhood Community Centers
Who cites it
19 citing papers in PubMed, 7 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Brain computer interfaces for cognitive enhancement in older people - challenges and applications: a systematic review.BMC geriatrics · 2025Pooled it
- Computerised cognitive training for 12 or more weeks for maintaining cognitive function in cognitively healthy people in late life.The Cochrane database of systematic reviews · 2020Pooled it
- Computerised cognitive training for preventing dementia in people with mild cognitive impairment.The Cochrane database of systematic reviews · 2019Pooled it
- Computerised cognitive training for maintaining cognitive function in cognitively healthy people in midlife.The Cochrane database of systematic reviews · 2019Pooled it
- Computerised cognitive training for maintaining cognitive function in cognitively healthy people in late life.The Cochrane database of systematic reviews · 2019Pooled it
- The effect of cognitive-based training for the healthy older people: A meta-analysis of randomized controlled trials.PloS one · 2017Pooled it
- A systematic review of hybrid brain-computer interfaces: Taxonomy and usability perspectives.PloS one · 2017Pooled it
- Motor imagery-based neurofeedback in older adults: neural signatures and feasibility in a randomized controlled trial targeting age-related cognitive decline.Journal of neuroengineering and rehabilitation · 2026Trial
- Article
- Microengineered neuronal networks: enhancing brain-machine interfaces.Annals of medicine and surgery (2012) · 2024Review
- Electroencephalography-Based Brain-Machine Interfaces in Older Adults: A Literature Review.Bioengineering (Basel, Switzerland) · 2023Review
- Methodology and preliminary data on feasibility of a neurofeedback protocol to improve visual attention to letters in mild Alzheimer's disease.Contemporary clinical trials communications · 2022Article
- Poststroke Cognitive Impairment Research Progress on Application of Brain-Computer Interface.BioMed research international · 2022Review
- Brain Exercising Games With Consumer-Grade Single-Channel Electroencephalogram Neurofeedback: Pre-Post Intervention Study.JMIR serious games · 2021Article
- Microglia and modifiable life factors: Potential contributions to cognitive resilience in aging.Behavioural brain research · 2021Review
- Evaluation of the Implementation and Effectiveness of Community-Based Brain-Computer Interface Cognitive Group Training in Healthy Community-Dwelling Older Adults: Randomized Controlled Implementation Trial.JMIR formative research · 2021Article
- CHI study: protocol for an observational cohort study on ageing and mental health in community-dwelling older adults.BMJ open · 2020Article
- Using brain-computer interfaces: a scoping review of studies employing social research methods.BMC medical ethics · 2019Article
- Brain-Computer Interface for Clinical Purposes: Cognitive Assessment and Rehabilitation.BioMed research international · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is growing evidence that cognitive training (CT) can improve the cognitive functioning of the elderly. CT may be influenced by cultural and linguistic factors, but research examining CT programs has mostly been conducted on Western populations. We have developed an innovative electroencephalography (EEG)-based brain-computer interface (BCI) CT program that has shown preliminary efficacy in improving cognition in 32 healthy English-speaking elderly adults in Singapore. In this second pilot trial, we examine the acceptability, safety, and preliminary efficacy of our BCI CT program in healthy Chinese-speaking Singaporean elderly.
methodsThirty-nine elderly participants were randomized into intervention (n=21) and wait-list control (n=18) arms. Intervention consisted of 24 half-hour sessions with our BCI-based CT training system to be completed in 8 weeks; the control arm received the same intervention after an initial 8-week waiting period. At the end of the training, a usability and acceptability questionnaire was administered. Efficacy was measured using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), which was translated and culturally adapted for the Chinese-speaking local population. Users were asked about any adverse events experienced after each session as a safety measure.
resultsThe training was deemed easily usable and acceptable by senior users. The median difference in the change scores pre- and post-training of the modified RBANS total score was 8.0 (95% confidence interval [CI]: 0.0-16.0, P=0.042) higher in the intervention arm than waitlist control, while the mean difference was 9.0 (95% CI: 1.7-16.2, P=0.017). Ten (30.3%) participants reported a total of 16 adverse events - all of which were graded "mild" except for one graded "moderate".
conclusionOur BCI training system shows potential in improving cognition in both English- and Chinese-speaking elderly, and deserves further evaluation in a Phase III trial. Overall, participants responded positively on the usability and acceptability questionnaire.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.