ReviewWorld journal of gastroenterology2015
Gastroesophageal reflux disease and non-esophageal cancer.
Review in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- The Association Between Gastroesophageal Reflux Disease and Lung Cancer: A Systematic Review and Meta Analysis.Journal of clinical medicine · 2026Review
- Linking Processed and Red Meat Consumption to Specific Lung Cancer Subtypes: A Mendelian Randomization Analysis.Current pharmaceutical biotechnology · 2026Article
- Gene-Diet interaction between FTO rs9939609 and fiber intake in relation to GERD susceptibility.Molecular biology reports · 2025Article
- Causal Relationship Between Cataracts and Gastrointestinal Diseases: A Two-Sample Mendelian Randomization Study.Translational vision science & technology · 2025Article
- Article
- A multi-level investigation of the genetic relationship between gastroesophageal reflux disease and lung cancer.Translational lung cancer research · 2024Article
- Gastroesophageal reflux disease and risk of incident lung cancer: A large prospective cohort study in UK Biobank.PloS one · 2024Article
- Gastroesophageal reflux disease and risk of cancer: Findings from the Korean National Health Screening Cohort.Cancer medicine · 2023Article
- Irritability and risk of lung cancer: a Mendelian randomization and mediation analysis.Journal of cancer research and clinical oncology · 2023Article
- Pleural Effusion as the Initial Presentation of Gastric Adenocarcinoma: A Case Report.The American journal of case reports · 2022Article
- The role of smoking and alcohol in mediating the effect of gastroesophageal reflux disease on lung cancer: A Mendelian randomization study.Frontiers in genetics · 2022Article
- Mind the Gap: Current Treatment Alternatives for GERD Patients Failing Medical Treatment and Not Ready for a Fundoplication.Surgical laparoscopy, endoscopy & percutaneous techniques · 2020Review
- Matrix association region/scaffold attachment region: the crucial player in defining the positions of chromosome breaks mediated by bile acid-induced apoptosis in nasopharyngeal epithelial cells.BMC medical genomics · 2019Article
- Article
- Beyond pancreatic insufficiency and liver disease in cystic fibrosis.European journal of pediatrics · 2016Review
- Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study.PeerJ · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association of gastroesophageal reflux disease (GERD) and esophageal cancer is well known. The carcinogenic properties of the gastroduodenal contents may also lead to cancer in target organs for GERD especially considering that they do not have intrinsic protective mechanisms as found in the esophagus. This review focuses on the putative relation between GERD and non-esophageal cancer. Most of the papers reviewed are far from ideal to prove the relationship of extra-esophageal cancer and GERD since a small number of patients is presented, most do not control cases based on tobacco usage and obesity, and the diagnosis of GERD is variable, not always from an objective measurement such as pH monitoring but relying on symptoms in most reports. Nevertheless, head and neck and lung cancer have a growing incidence parallel to GERD and a shift towards non-smoking, female gender and adenocarcinoma (compared to squamous cell carcinoma) is arising, similar to the example of esophageal cancer with the exception of the female gender.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.