ArticleJournal of Indian Society of Periodontology
Comparative evaluation of salivary soluble CD44 levels in periodontal health and disease.
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- The association between oral hygiene and periodontitis: a systematic review and meta-analysis.International dental journal · 2017Pooled it
- Current Evidence and Perspectives of Cluster of Differentiation 44 in the Liver's Physiology and Pathology.International journal of molecular sciences · 2024Review
- Salivary Soluble CD44 Level in Chronic Periodontitis - A Comparative Assessment between Preoperative and Postoperative Scaling and Root Planing.Journal of pharmacy & bioallied sciences · 2023Article
- Decreased Levels of Soluble CD44 in a High-Risk Population following a Smoking Cessation Program.International journal of environmental research and public health · 2021Article
- Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues.Cancers · 2021Article
- Proteolytic Processing of CD44 and Its Implications in Cancer.Stem cells international · 2021Review
- Article
- Determination of Salivary CD44 as a Noninvasive Diagnostic Biomarker to Predict Malignant Transformation of Oral Submucous Fibrosis.Contemporary clinical dentistryArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextInflammation, immunoactivation, and malignant diseases are associated with increased plasma levels of soluble CD44 (sCD44). Serum sCD44 has been recognized as a diagnostic marker in smoking-induced diseases.
aim(1) To assess the levels of salivary sCD44 in periodontal health and disease. (2) To compare the levels of salivary sCD44 in smokers and nonsmokers. (3) To assess if salivary sCD44 levels could be used as a diagnostic marker for periodontitis. SETTING AND
designA total of 60 patients were divided into three groups viz. Group A - healthy, Group B - aggressive periodontitis and Group C - chronic periodontitis (Subdivided into C1 - chronic periodontitis smokers and C2 - chronic periodontitis nonsmokers). MATERIALS AND
methodsThe plaque index, gingival index (GI), probing depth and clinical attachment level; along with the radiographs were recorded. The saliva sample collected at baseline was stored at -80°C. The sCD44 levels were analyzed using ELISA. STATISTICAL ANALYSIS USED: ANOVA test and Mann-Whitney's test was used to compare readings between all the groups and Pearson correlation was calculated for CD44 and all the clinical parameters in each group.
resultsHighest mean sCD44 was recorded in Group C2 followed by Group C1. The GI was positively correlated with CD44 levels in chronic periodontitis group. Contrary to previous reports nonsmokers subjects had higher CD44 levels as compared to smoker.
conclusionSoluble CD44 levels were positively correlated with periodontal disease. Thus, salivary sCD44 could be considered as a one of the biomarker for periodontitis that is, aggressive and chronic periodontitis.
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