ArticleProceedings of the National Academy of Sciences of the United States of America2015
Therapeutic mechanisms of high-frequency stimulation in Parkinson's disease and neural restoration via loop-based reinforcement.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- In silico model of basal ganglia deep brain stimulation in Parkinson's disease captures range of effective parameters for pathological beta power suppression.PLoS computational biology · 2026Article
- High-frequency, low-energy organic event-based sensors for closed-loop neurostimulation.Nature sensors · 2026Article
- CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making.PloS one · 2025Article
- Magnitude-constrained optimal chaotic desynchronization of neural populations.Frontiers in network physiology · 2025Article
- Push-pull effects of basal ganglia network in Parkinson's disease inferred by functional MRI.NPJ Parkinson's disease · 2024Article
- CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making.bioRxiv : the preprint server for biology · 2024Article
- Brain-computer interfaces for neuropsychiatric disorders.Nature reviews bioengineering · 2024Article
- Does Impaired Plantar Cutaneous Vibration Perception Contribute to Axial Motor Symptoms in Parkinson's Disease? Effects of Medication and Subthalamic Nucleus Deep Brain Stimulation.Brain sciences · 2023Article
- Differential spatiotemporal gait effects with frequency and dopaminergic modulation in STN-DBS.Frontiers in aging neuroscience · 2023Article
- Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Brain stimulation competes with ongoing oscillations for control of spike timing in the primate brain.PLoS biology · 2022Article
- Deep brain stimulation for movement disorder treatment: exploring frequency-dependent efficacy in a computational network model.Biological cybernetics · 2022Article
- Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation.Frontiers in cellular neuroscience · 2022Article
- Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation.Nature biomedical engineering · 2021Article
- Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson's disease.Communications biology · 2021Article
- An Introspective Approach: A Lifetime of Parkinson's Disease Research and Not Much to Show for it Yet?Cells · 2021Article
- Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence.Nature communications · 2021Article
- Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson's disease for 1 year.CNS neuroscience & therapeutics · 2020Article
- Models of communication and control for brain networks: distinctions, convergence, and future outlook.Network neuroscience (Cambridge, Mass.) · 2020Article
- Adaptive delivery of continuous and delayed feedback deep brain stimulation - a computational study.Scientific reports · 2019Article
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6 authors.
Funding
Abstract
High-frequency deep brain stimulation (HFS) is clinically recognized to treat parkinsonian movement disorders, but its mechanisms remain elusive. Current hypotheses suggest that the therapeutic merit of HFS stems from increasing the regularity of the firing patterns in the basal ganglia (BG). Although this is consistent with experiments in humans and animal models of Parkinsonism, it is unclear how the pattern regularization would originate from HFS. To address this question, we built a computational model of the cortico-BG-thalamo-cortical loop in normal and parkinsonian conditions. We simulated the effects of subthalamic deep brain stimulation both proximally to the stimulation site and distally through orthodromic and antidromic mechanisms for several stimulation frequencies (20-180 Hz) and, correspondingly, we studied the evolution of the firing patterns in the loop. The model closely reproduced experimental evidence for each structure in the loop and showed that neither the proximal effects nor the distal effects individually account for the observed pattern changes, whereas the combined impact of these effects increases with the stimulation frequency and becomes significant for HFS. Perturbations evoked proximally and distally propagate along the loop, rendezvous in the striatum, and, for HFS, positively overlap (reinforcement), thus causing larger poststimulus activation and more regular patterns in striatum. Reinforcement is maximal for the clinically relevant 130-Hz stimulation and restores a more normal activity in the nuclei downstream. These results suggest that reinforcement may be pivotal to achieve pattern regularization and restore the neural activity in the nuclei downstream and may stem from frequency-selective resonant properties of the loop.
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