ArticleProceedings of the National Academy of Sciences of the United States of America2015
Flagella-independent surface motility in Salmonella enterica serovar Typhimurium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Motility Matters: Quantitative Analysis of Salmonella Swimming and Swarming.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Phase variation of Clostridioides difficile colony morphology occurs via modulation of cell division.PLoS pathogens · 2025Article
- Swashing: a propulsion-independent form of bacterial surface migration.Journal of bacteriology · 2025Article
- An updated overview on the bacterial PhoP/PhoQ two-component signal transduction system.Frontiers in cellular and infection microbiology · 2025Review
- Only time will tell: lipopolysaccharide glycoform and biofilm-formation kinetics inJournal of bacteriology · 2024Review
- Swashing motility: A novel propulsion-independent mechanism for surface migration inbioRxiv : the preprint server for biology · 2024Article
- Virulence genes identification inVeterinary world · 2023Article
- Exopolysaccharides amylovoran and levan contribute to sliding motility in the fire blight pathogen Erwinia amylovora.Environmental microbiology · 2022Article
- Patatin-like phospholipase CapV in Escherichia coli - morphological and physiological effects of one amino acid substitution.NPJ biofilms and microbiomes · 2022Article
- Flagella at the Host-Microbe Interface: Key Functions Intersect With Redundant Responses.Frontiers in immunology · 2022Review
- How the PhoP/PhoQ System Controls Virulence and MgMicrobiology and molecular biology reviews : MMBR · 2021Review
- Transient surface hydration impacts biogeography and intercellular interactions of non-motile bacteria.Applied and environmental microbiology · 2021Article
- Correlation Between Pathogenic Determinants Associated with Clinically Isolated Non-TyphoidalPathogens (Basel, Switzerland) · 2021Article
- QseC Signaling in the Outbreak O104:H4Journal of bacteriology · 2019Article
- A Novel Single Domain Antibody Targeting FliC Flagellin ofFrontiers in microbiology · 2019Article
- Identification and phase inversion of Salmonella flagellar antigens, using immuno-discs.The Journal of veterinary medical science · 2018Article
- Assessing Travel Conditions: Environmental and Host Influences On Bacterial Surface Motility.Journal of bacteriology · 2018Article
- Monitoring Spatial Segregation in Surface Colonizing Microbial Populations.Journal of visualized experiments : JoVE · 2016Article
- When Too Much ATP Is Bad for Protein Synthesis.Journal of molecular biology · 2015Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Flagella are multiprotein complexes necessary for swimming and swarming motility. In Salmonella enterica serovar Typhimurium, flagella-mediated motility is repressed by the PhoP/PhoQ regulatory system. We now report that Salmonella can move on 0.3% agarose media in a flagella-independent manner when experiencing the PhoP/PhoQ-inducing signal low Mg(2+). This motility requires the PhoP-activated mgtA, mgtC, and pagM genes, which specify a Mg(2+) transporter, an inhibitor of Salmonella's own F1Fo ATPase, and a small protein of unknown function, respectively. The MgtA and MgtC proteins are necessary for pagM expression because pagM mRNA levels were lower in mgtA and mgtC mutants than in wild-type Salmonella, and also because pagM expression from a heterologous promoter rescued motility in mgtA and mgtC mutants. PagM promotes group motility by a surface protein(s), as a pagM-expressing strain conferred motility upon a pagM null mutant, and proteinase K treatment eliminated motility. The pagM gene is rarely found outside subspecies I of S. enterica and often present in nonfunctional allelic forms in organisms lacking the identified motility. Deletion of the pagM gene reduced bacterial replication on 0.3% agarose low Mg(2+) media but not in low Mg(2+) liquid media. Our findings define a form of motility that allows Salmonella to scavenge nutrients and to escape toxic compounds in low Mg(2+) semisolid environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.