SynthesisJournal of medical genetics2015
DCAF4, a novel gene associated with leucocyte telomere length.
Synthesis in Journal of medical genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 5 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes.Nature communications · 2024Pooled it
- Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies.Nature communications · 2019Pooled it
- Physical activity, cardiorespiratory fitness and risk of cutaneous malignant melanoma: Systematic review and meta-analysis.PloS one · 2018Pooled it
- Functional variants in DCAF4 associated with lung cancer risk in European populations.Carcinogenesis · 2017Pooled it
- Telomere structure and maintenance gene variants and risk of five cancer types.International journal of cancer · 2016Pooled it
- Genetic Determinants of Telomere Length and Their Role in Human Disease: Molecular Mechanisms and Underrepresented Populations' Perspectives.Biomedicines · 2026Review
- Genomic, phenomic and geographic associations of leukocyte telomere length in the United States.Nature genetics · 2026Article
- A parent-of-origin effect on embryonic telomere elongation determines telomere length inheritance.Current biology : CB · 2025Article
- A novel machine learning approach for tumor detection based on telomeric signatures.Biology methods & protocols · 2025Article
- Telomere length and cancer risk: finding Goldilocks.Biogerontology · 2024Review
- Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality.Nature medicine · 2023Article
- Telomeres are shorter in wild Saccharomyces cerevisiae isolates than in domesticated ones.Genetics · 2023Article
- Article
- Association between leukocyte telomere length and COVID-19 severity.The Egyptian journal of medical human genetics · 2023Article
- Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study.Scientific reports · 2022Article
- Relationship between genetically determined telomere length and glioma risk.Neuro-oncology · 2022Article
- Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed.Cell genomics · 2022Article
- Genetic regulation of newborn telomere length is mediated and modified by DNA methylation.Frontiers in genetics · 2022Article
- Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy.Journal of personalized medicine · 2021Article
- Article
Corrections and comments
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Authors and funding
31 authors at 19 institutions in 6 countries.
Funding
Abstract
backgroundLeucocyte telomere length (LTL), which is fashioned by multiple genes, has been linked to a host of human diseases, including sporadic melanoma. A number of genes associated with LTL have already been identified through genome-wide association studies. The main aim of this study was to establish whether DCAF4 (DDB1 and CUL4-associated factor 4) is associated with LTL. In addition, using ingenuity pathway analysis (IPA), we examined whether LTL-associated genes in the general population might partially explain the inherently longer LTL in patients with sporadic melanoma, the risk for which is increased with ultraviolet radiation (UVR).
resultsGenome-wide association (GWA) meta-analysis and de novo genotyping of 20 022 individuals revealed a novel association (p=6.4×10(-10)) between LTL and rs2535913, which lies within DCAF4. Notably, eQTL analysis showed that rs2535913 is associated with decline in DCAF4 expressions in both lymphoblastoid cells and sun-exposed skin (p=4.1×10(-3) and 2×10(-3), respectively). Moreover, IPA revealed that LTL-associated genes, derived from GWA meta-analysis (N=9190), are over-represented among genes engaged in melanoma pathways. Meeting increasingly stringent p value thresholds (p<0.05, <0.01, <0.005, <0.001) in the LTL-GWA meta-analysis, these genes were jointly over-represented for melanoma at p values ranging from 1.97×10(-169) to 3.42×10(-24).
conclusionsWe uncovered a new locus associated with LTL in the general population. We also provided preliminary findings that suggest a link of LTL through genetic mechanisms with UVR and melanoma in the general population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.