Evidence map›Paper›PMID 25624416›Full record

ArticleJournal of Alzheimer's disease : JAD2015

Estimating the risk for conversion from mild cognitive impairment to Alzheimer's disease in an elderly Arab community.

Rivka Inzelberg, Magda Massarwa, Edna Schechtman, Rosa Strugatsky, Lindsay A Farrer, Robert P Friedland

Abstract read
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In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rivka InzelbergDepartment of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Israel The Sagol Neuroscience Center, Department of Neurology, Sheba Medical Center, Israel.
Magda MassarwaDepartment of Neurology, Hillel Yaffe Medical Center, Hadera, Israel.
Edna SchechtmanDepartment of Industrial Engineering and Management, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Rosa StrugatskyThe Sagol Neuroscience Center, Department of Neurology, Sheba Medical Center, Israel.
Lindsay A FarrerDepartments of Medicine (Genetics Program), Neurology, Ophthalmology, Genetics & Genomics, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, USA.
Robert P FriedlandDepartment of Neurology, University of Louisville, Kentucky, USA.

Funding

Genetics of Alzheimer's Disease in Israeli ArabsR01AG017173 · NIA · UNIVERSITY OF LOUISVILLE · PI FRIEDLAND, ROBERT PAUL · 2005 to 2009
$5.4M
NIA NIH HHS R01 AG017173
6 · The paper itself

Abstract

backgroundVascular risk factors and lack of formal education may increase the risk of Alzheimer's disease (AD).

objectiveTo determine the contribution of vascular risk factors and education to the risk of mild cognitive impairment (MCI) and AD and to estimate the risk for conversion from MCI to AD.

methodsThis door-to-door survey was performed by an Arab-speaking team in Wadi Ara villages in Israel. All consenting residents aged ≥ 65 years were interviewed for medical history and underwent neurological and cognitive examinations. Individuals were cognitively classified as normal (CN), MCI, AD, vascular dementia, or unclassifiable. MCI patients were re-examined at least one year later to determine conversion to AD. The contributions of age, gender, school years, and vascular risk factors to the probability of conversion were estimated using logistic regression models.

resultsOf the 906 participants, 297 (33%) had MCI and 95 (10%) had AD. Older age (p = 0.0008), female gender (p = 0.023), low schooling (p < 0.0001), and hypertension (p = 0.0002) significantly accounted for risk of MCI versus CN, and diabetes was borderline (p = 0.051). The risk of AD versus CN was significantly associated with age (p < 0.0001), female gender (p < 0.0001), low schooling (p = 0.004) and hypertension (p = 0.049). Of the 231 subjects with MCI that were re-examined, 65 converted to AD.

conclusionsIn this population, age, female gender, lack of formal education, and hypertension are risk factors for both AD and MCI. Conversion risk from MCI to AD could be estimated as a function of age, time interval between examinations, and hypertension.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseArabsBlood PressureCognition DisordersDisease ProgressionEducational StatusFemaleHumansIsraelLogistic ModelsMaleProbabilityResidence CharacteristicsRisk FactorsAgingAlzheimer's diseaseArabmild cognitive impairmentneuroepidemiologyprevalencerisk factors

Identifiers

PMID25624416
PMCPMC8052587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.