ArticleThe Journal of cell biology2015
Unipotent, Atoh1+ progenitors maintain the Merkel cell population in embryonic and adult mice.
Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 47 citations in OpenAlex.
- Developmental chronology of mouse embryo from 2-cell stage through birth.Nature cell biology · 2026Article
- Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Development and regeneration of Merkel cells.Current topics in developmental biology · 2025Review
- Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle.Nature communications · 2024Article
- Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages.Science advances · 2024Article
- Merkel cell carcinoma: updates in tumor biology, emerging therapies, and preclinical models.Frontiers in oncology · 2024Review
- Feline papillomavirus-associated Merkel cell carcinoma: a comparative review with human Merkel cell carcinoma.The Journal of veterinary medical science · 2023Review
- Merkel Cell Polyomavirus T Antigen-Mediated Reprogramming in Adult Merkel Cell Progenitors.The Journal of investigative dermatology · 2023Article
- Review
- IL-17RA-signaling in Lgr5Immunity · 2022Article
- Specialized Mechanosensory Epithelial Cells in Mouse Gut Intrinsic Tactile Sensitivity.Gastroenterology · 2022Article
- Article
- Reciprocal signals between nerve and epithelium: how do neurons talk with epithelial cells?American journal of stem cells · 2021Review
- Atonal bHLH transcription factor 1 is an important factor for maintaining the balance of cell proliferation and differentiation in tumorigenesis.Oncology letters · 2020Review
- Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis.Nature cell biology · 2020Article
- A novel player in the field: Merkel disc in touch, itch and pain.Experimental dermatology · 2019Article
- Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma.Neoplasia (New York, N.Y.) · 2019Article
- The touchy business of gastrointestinal (GI) mechanosensitivity.Brain research · 2018Review
- Mechanosensitive ion channel Piezo1 is expressed in antral G cells of murine stomach.Cell and tissue research · 2018Article
- Merkel Cell Polyomavirus Small T Antigen Initiates Merkel Cell Carcinoma-like Tumor Development in Mice.Cancer research · 2017Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Resident progenitor cells in mammalian skin generate new cells as a part of tissue homeostasis. We sought to identify the progenitors of Merkel cells, a unique skin cell type that plays critical roles in mechanosensation. We found that some Atoh1-expressing cells in the hairy skin and whisker follicles are mitotically active at embryonic and postnatal ages. Genetic fate-mapping revealed that these Atoh1-expressing cells give rise solely to Merkel cells. Furthermore, selective ablation of Atoh1(+) skin cells in adult mice led to a permanent reduction in Merkel cell numbers, demonstrating that other stem cell populations are incapable of producing Merkel cells. These data identify a novel, unipotent progenitor population in the skin that gives rise to Merkel cells both during development and adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.