ArticleHypertension (Dallas, Tex. : 1979)2015
Effect of aldosterone-producing adenoma on endothelial function and Rho-associated kinase activity in patients with primary aldosteronism.
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Article in Hypertension (Dallas, Tex. : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Prospective study of primary aldosteronism in acute ischemic stroke: association with small vessel disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Non-Hypertensive Effects of Aldosterone.International journal of molecular sciences · 2025Review
- Recent progress in unraveling cardiovascular complications associated with primary aldosteronism: a succinct review.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Salt and Aldosterone - Reciprocal and Combined Effects in Preclinical Models and Humans.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2024Review
- KCNJ5 mutation is a predictor for recovery of endothelial function after adrenalectomy in patients with aldosterone-producing adenoma.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Cardiovascular Disease in Obstructive Sleep Apnea: Putative Contributions of Mineralocorticoid Receptors.International journal of molecular sciences · 2023Review
- Serum Potassium Levels of 4.5 to Less Than 5.0 mmol/L Are Associated with Better Vascular Function.Journal of atherosclerosis and thrombosis · 2022Article
- Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma.Molecular and cellular endocrinology · 2022Article
- Primary Aldosteronism and Resistant Hypertension: A Pathophysiological Insight.International journal of molecular sciences · 2022Review
- Atrial Fibrillation and Aortic Ectasia as Complications of Primary Aldosteronism: Focus on Pathophysiological Aspects.International journal of molecular sciences · 2022Review
- Clinical impacts of endothelium-dependent flow-mediated vasodilation assessment on primary aldosteronism.Endocrine connections · 2021Article
- Evaluation of Abdominal Computed Tomography Scans for Differentiating the Discrepancies in Abdominal Adipose Tissue Between Two Major Subtypes of Primary Aldosteronism.Frontiers in endocrinology · 2021Article
- Plasma levels of the cardiovascular protective endogenous nucleoside adenosine are reduced in patients with primary aldosteronism without affecting ischaemia-reperfusion injury: A prospective case-control study.European journal of clinical investigation · 2019Article
- Endothelial Dysfunction in Primary Aldosteronism.International journal of molecular sciences · 2019Review
- Hypertension with primary aldosteronism is associated with increased carotid intima-media thickness and endothelial dysfunction.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Microvascular and macrovascular endothelial function in two different types of primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study.Journal of hypertension · 2019Observational
- Predictors of confirmatory test results for the diagnosis of primary hyperaldosteronism in hypertensive patients with an aldosterone-to-renin ratio greater than 20. The SHRIMP study.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Microvascular endothelial function is impaired in patients with idiopathic hyperaldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Effect of Ivabradine on a Hypertensive Heart and the Renin-Angiotensin-Aldosterone System inInternational journal of molecular sciences · 2018Article
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Authors and funding
17 authors at 3 institutions in 1 country.
Takeshi MatsumotoFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Kenji OkiFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Masato KajikawaFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Ayumu NakashimaFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Tatsuya MaruhashiFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Yumiko IwamotoFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Akimichi IwamotoFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Nozomu OdaFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Takayuki HidakaFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Yasuki KiharaFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Nobuoki KohnoFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Kazuaki ChayamaFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Chikara GotoFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Yoshiki AibaraFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Kensuke NomaFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
James K LiaoFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.).
Yukihito HigashiFrom the Departments of Cardiovascular Medicine (T. Matsumoto, M.K., T. Maruhashi, Y.I., A.I., N.O., T.H., Y.K.) and Molecular and Internal Medicine (K.O., N.K.), Graduate School of Biomedical and Health Sciences, Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences (K.C.), and Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.A., K.N., Y.H.), Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (A.N., Y.H.); Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan (C.G.); and Section of Cardiology, University of Chicago Medical Center, IL (J.K.L.). yhigashi@hiroshima-u.ac.jp.
Hiroshima University Hospital · JPHiroshima International University · JPHiroshima University · JP
Funding
LIPOPROTEINS EFFECTS ON G PROTEIN FUNCTIONR01HL052233 · NHLBI · UNIVERSITY OF CHICAGO · PI LIAO, JAMES KUANG-JAN · 1995 to 2016
$5.3MNHLBI NIH HHS HL052233NHLBI NIH HHS R01 HL052233
Abstract
The purpose of this study was to evaluate vascular function and activity of Rho-associated kinases (ROCKs) in patients with primary aldosteronism. Vascular function, including flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation, and ROCK activity in peripheral leukocytes were evaluated in 21 patients with aldosterone-producing adenoma (APA), 23 patients with idiopathic hyperaldosteronism (IHA), and 40 age-, sex-, and blood pressure-matched patients with essential hypertension (EHT). FMD was significantly lower in the APA group than in the IHA and EHT groups (3.2±2.0% versus 4.6±2.3% and 4.4±2.2%; P<0.05, respectively), whereas there was no significant difference in FMD between the IHA and EHT groups. There was no significant difference in nitroglycerine-induced vasodilation in the 3 groups. ROCK activity was higher in the APA group than in the IHA and EHT groups (1.29±0.57 versus 1.00±0.46 and 0.81±0.36l; P<0.05, respectively), whereas there was no significant difference in ROCK activity between the IHA and EHT groups. FMD correlated with age (r=-0.31; P<0.01), plasma aldosterone concentration (r=-0.35; P<0.01), and aldosterone:renin ratio (r=-0.34; P<0.01). ROCK activity correlated with age (r=-0.24; P=0.04), plasma aldosterone concentration (r=0.33; P<0.01), and aldosterone:renin ratio (r=0.46; P<0.01). After adrenalectomy, FMD and ROCK activity were restored in patients with APA. APA was associated with both endothelial dysfunction and increased ROCK activity compared with those in IHA and EHT. APA may have a higher risk of future cardiovascular events.
Indexed as
AdenomaAdultAldosteroneBlood PressureEndothelium, VascularFemaleFollow-Up StudiesHumansHyperaldosteronismHypertensionMaleMiddle Agedrho-Associated KinasesVasodilationAldosteronerho-Associated KinasesaldosteronehyperaldosteronismhypertensionRho-associated kinases
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