Evidence map›Paper›PMID 25624315›Full record

ArticleGenetics2015

Fruit flies in biomedical research.

Michael F Wangler, Shinya Yamamoto, Hugo J Bellen

Abstract read
In one paragraph

Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed.

  1. A Landscape ofBiology · 2026
    Review
  2. Phytochemical Analysis and Bioevaluation ofAntioxidants (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Special Issue "International journal of molecular sciences · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. International journal of molecular sciences · 2025
    Review
  10. Article
  11. Article
  12. Infection and immunity · 2025
    Review
  13. Review
  14. Pathogens (Basel, Switzerland) · 2024
    Review
  15. Enhanced Protein-Protein Interaction Discovery via AlphaFold-Multimer.bioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. International journal of biological sciences · 2024
    Article
  18. Article
  19. Article
  20. Review

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael F WanglerDepartment of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, Texas 77030 Department of Pediatrics, Baylor College of Medicine (BCM), Houston, Texas 77030 Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030.ORCID http://orcid.org/0000-0001-5245-5910
Shinya YamamotoDepartment of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, Texas 77030 Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030 Program in Developmental Biology, Baylor College of Medicine (BCM), Texas 77030.ORCID http://orcid.org/0000-0003-2172-8036
Hugo J BellenDepartment of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, Texas 77030 Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030 Program in Developmental Biology, Baylor College of Medicine (BCM), Texas 77030 Department of Neuroscience, Baylor College of Medicine (BCM), Texas 77030 Howard Hughes Medical Institute, Houston, Texas 77030 hbellen@bcm.edu.ORCID http://orcid.org/0000-0001-5992-5989

Funding

Transposon induced disruption of most Drosophila genesR01GM067858 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J · 2003 to 2020
$15.7M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
Genomic medicine and gene function implementation for an underserved populationR01HG011795 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J, WANGLER, MICHAEL FRANCIS · 2021 to 2025
$4.8M
Mapping and rescuing EMS-induced lethal mutations on the Drosophila X ChromosomeRC4GM096355 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J · 2010 to 2010
$1.7M
Neuronal Mechanisms of Peroxisomal Biogenesis Defects in DrosophilaK08NS076547 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI WANGLER, MICHAEL FRANCIS · 2011 to 2015
$729k
NHGRI NIH HHS R01 HG011795NICHD NIH HHS U54 HD083092NIGMS NIH HHS 1RC4GM096355NIGMS NIH HHS 2R01GM067858NIGMS NIH HHS R01 GM067858NIGMS NIH HHS RC4 GM096355NINDS NIH HHS K08 NS076547NINDS NIH HHS NS076547
6 · The paper itself

Abstract

Many scientists complain that the current funding situation is dire. Indeed, there has been an overall decline in support in funding for research from the National Institutes of Health and the National Science Foundation. Within the Drosophila field, some of us question how long this funding crunch will last as it demotivates principal investigators and perhaps more importantly affects the long-term career choice of many young scientists. Yet numerous very interesting biological processes and avenues remain to be investigated in Drosophila, and probing questions can be answered fast and efficiently in flies to reveal new biological phenomena. Moreover, Drosophila is an excellent model organism for studies that have translational impact for genetic disease and for other medical implications such as vector-borne illnesses. We would like to promote a better collaboration between Drosophila geneticists/biologists and human geneticists/bioinformaticians/clinicians, as it would benefit both fields and significantly impact the research on human diseases.

Indexed as

Genetic ResearchAnimalsDrosophilaGenetic Diseases, InbornGenomicsHumansNational Institutes of Health (U.S.)United StatescollaborationDrosophilafunctional genomicsfundinggenetic diseaseGWAShumanpublic healthwhole-exome sequencing

Identifiers

PMID25624315
PMCPMC4349060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.