ArticleDevelopmental biology2015
Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 55 citations in OpenAlex.
- Ecdysone receptor autonomously controls germ cell differentiation in the Drosophila ovary.Development (Cambridge, England) · 2026Article
- Photoreceptor control ofProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sex-Specific Response to Predator Auditory Cues in Asian Corn Borer (Ecology and evolution · 2026Article
- Transcriptional Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- Article
- Avian malaria and the overlooked metabolic pathways underlying mosquitoRoyal Society open science · 2025Article
- Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways.Communications biology · 2023Article
- Cyromazine affects the ovarian germ cells ofFrontiers in physiology · 2022Article
- Review
- The Drosophila E78 nuclear receptor regulates dietary triglyceride uptake and systemic lipid levels.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Orphan nuclear receptor ftz-f1 (NR5A3) promotes egg chamber survival in the Drosophila ovary.G3 (Bethesda, Md.) · 2021Article
- Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit FlyFrontiers in physiology · 2021Review
- Nuclear receptors linking physiology and germline stem cells in Drosophila.Vitamins and hormones · 2021Review
- Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila.Scientific reports · 2020Article
- Co-infection of Wolbachia and Spiroplasma in spider mite Tetranychus truncatus increases male fitness.Insect science · 2020Article
- Molecular Characterization and Expression Profiling of Nuclear Receptor Gene Families in Oriental Fruit Fly,Insects · 2020Article
- The nuclear receptor seven up functions in adipocytes and oenocytes to control distinct steps of Drosophila oogenesis.Developmental biology · 2019Article
- Novel cis-regulatory regions in ecdysone responsive genes are sufficient to promote gene expression in Drosophila ovarian cells.Gene expression patterns : GEP · 2019Article
- Review
- Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner.PLoS biology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Nuclear hormone receptors have emerged as important regulators of mammalian and Drosophila adult physiology, affecting such seemingly diverse processes as adipogenesis, carbohydrate metabolism, circadian rhythm, stem cell function, and gamete production. Although nuclear hormone receptors Ecdysone Receptor (EcR) and Ultraspiracle (Usp) have multiple known roles in Drosophila development and regulate key processes during oogenesis, the adult function of the majority of nuclear hormone receptors remains largely undescribed. Ecdysone-induced protein 78C (E78), a nuclear hormone receptor closely related to Drosophila E75 and to mammalian Rev-Erb and Peroxisome Proliferator Activated Receptors, was originally identified as an early ecdysone target; however, it has remained unclear whether E78 significantly contributes to adult physiology or reproductive function. To further explore the biological function of E78 in oogenesis, we used available E78 reporters and created a new E78 loss-of-function allele. We found that E78 is expressed throughout the germline during oogenesis, and is important for proper egg production and for the maternal control of early embryogenesis. We showed that E78 is required during development to establish the somatic germline stem cell (GSC) niche, and that E78 function in the germline promotes the survival of developing follicles. Consistent with its initial discovery as an ecdysone-induced target, we also found significant genetic interactions between E78 and components of the ecdysone-signaling pathway. Taken together with the previously described roles of EcR, Usp, and E75, our results suggest that nuclear hormone receptors are critical for the broad transcriptional control of a wide variety of cellular processes during oogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.