ReviewEndocrine-related cancer2015
Persistent organic pollutants and obesity: are they potential mechanisms for breast cancer promotion?
Review in Endocrine-related cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- A Systematic Review of Environmental Health Outcomes in Selected American Indian and Alaska Native Populations.Journal of racial and ethnic health disparities · 2020Pooled it
- Article
- Housing characteristics, dietary patterns, and sociodemographic characteristics as predictors of persistent organic pollutant exposure among African American pregnant women in Atlanta.Environmental research · 2025Article
- Exposure to air pollutants and breast cancer risk: mediating effects of metabolic health biomarkers in a nested case-control study within the E3N-Generations cohort.Breast cancer research : BCR · 2024Article
- Early detection of breast cancer through the diagnosis of Nipple Aspirate Fluid (NAF).Clinical proteomics · 2024Review
- Air Quality and Cancer Prevalence Trends across the Sub-Saharan African Regions during 2005-2020.International journal of environmental research and public health · 2022Article
- Prenatal Environmental Exposure to Persistent Organic Pollutants and Indices of Overweight and Cardiovascular Risk in Dutch Adolescents.Nutrients · 2022Observational
- Temporal Trends of Exposure to Organochlorine Pesticides in the United States: A Population Study from 2005 to 2016.International journal of environmental research and public health · 2022Article
- Why We Will Continue to Lose Our Battle with Cancers If We Do Not Stop Their Triggers from Environmental Pollution.International journal of environmental research and public health · 2021Review
- Potential therapeutic applications of the gut microbiome in obesity: from brain function to body detoxification.International journal of obesity (2005) · 2020Review
- Garbage in garbage out: the contribution of our industrial advancement to wastewater degeneration.Environmental science and pollution research international · 2020Review
- Serum concentrations of DDE, PCBs, and other persistent organic pollutants and mammographic breast density in Triana, Alabama, a highly exposed population.Environmental research · 2020Article
- Genome Mining and Comparative Pathogenomic Analysis of An Endemic Methicillin-ResistantPathogens (Basel, Switzerland) · 2019Article
- Persistent Organic Pollutants and Breast Cancer: A Systematic Review and Critical Appraisal of the Literature.Cancers · 2019Review
- The role of pollutants in type 2 diabetes mellitus (T2DM) and their prospective impact on phytomedicinal treatment strategies.Environmental monitoring and assessment · 2018Article
- Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort.Epigenetics · 2018Article
- Evaluation of nipple aspirate fluid as a diagnostic tool for early detection of breast cancer.Clinical proteomics · 2018Review
- Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study.Environmental health : a global access science source · 2017Article
- Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties.International journal of environmental research and public health · 2017Article
- Marine-Derived Biocatalysts: Importance, Accessing, and Application in Aromatic Pollutant Bioremediation.Frontiers in microbiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Dietary ingestion of persistent organic pollutants (POPs) is correlated with the development of obesity. Obesity alters metabolism, induces an inflammatory tissue microenvironment, and is also linked to diabetes and breast cancer risk/promotion of the disease. However, no direct evidence exists with regard to the correlation among all three of these factors (POPs, obesity, and breast cancer). Herein, we present results from current correlative studies indicating a causal link between POP exposure through diet and their bioaccumulation in adipose tissue that promotes the development of obesity and ultimately influences breast cancer development and/or progression. Furthermore, as endocrine disruptors, POPs could interfere with hormonally responsive tissue functions causing dysregulation of hormone signaling and cell function. This review highlights the critical need for advanced in vitro and in vivo model systems to elucidate the complex relationship among obesity, POPs, and breast cancer, and, more importantly, to delineate their multifaceted molecular, cellular, and biochemical mechanisms. Comprehensive in vitro and in vivo studies directly testing the observed correlations as well as detailing their molecular mechanisms are vital to cancer research and, ultimately, public health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.