ArticleCerebellum (London, England)2015
Vestibular Performance During High-Acceleration Stimuli Correlates with Clinical Decline in SCA6.
Article in Cerebellum (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Best Oculomotor Endpoints for Clinical Trials in Hereditary Ataxias: A Systematic Review and Consensus by the Ataxia Global Initiative Working Group on Digital‑Motor Biomarkers.Cerebellum (London, England) · 2025Pooled it
- Quantitative Oculomotor and Vestibular Profile in Spinocerebellar Ataxia Type 6 - Systematic Review and Meta-Analysis.Cerebellum (London, England) · 2024Pooled it
- Quantitative Oculomotor Assessment in Hereditary Ataxia: Discriminatory Power, Correlation with Severity Measures, and Recommended Parameters for Specific Genotypes.Cerebellum (London, England) · 2024Article
- Clinical value of vestibulo-ocular reflex in the differentiation of spinocerebellar ataxias.Scientific reports · 2023Article
- Visual oculomotor abnormalities and vestibulo‑ocular reflex dynamics in polyglutamine spinocerebellar ataxias (Review).Experimental and therapeutic medicine · 2023Review
- Bilateral vestibulopathy: a clinical update and proposed diagnostic algorithm.Frontiers in neurology · 2023Review
- Article
- Head-impulse tests aid in differentiation of multiple system atrophy from Parkinson's disease.Journal of neurology · 2022Article
- Vestibular impairments in episodic ataxia type 2.Journal of neurology · 2022Article
- An Algorithm for the Diagnosis of Vestibular, Cerebellar, and Oculomotor Disorders Using a Systematized Clinical Bedside Examination.Cerebellum (London, England) · 2021Article
- Evolution of caloric responses during and between the attacks of Meniere's disease.Journal of neurology · 2021Article
- Case Report: Bow Hunter Syndrome-One Reason to Add Non-gravity Dependent Positional Nystagmus Testing to Your Clinical Neuro-Otologic Exam.Frontiers in neurology · 2021Article
- Evolution of the vestibular function during head impulses in spinocerebellar ataxia type 6.Journal of neurology · 2020Article
- Eye Movement Disorders and the Cerebellum.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2019Review
- Abnormal Eye Movements in Parkinsonism and Movement Disorders.Journal of movement disorders · 2019Article
- Consensus Paper: Neurophysiological Assessments of Ataxias in Daily Practice.Cerebellum (London, England) · 2018Review
- The Floccular Syndrome: Dynamic Changes in Eye Movements and Vestibulo-ocular Reflex in Isolated Infarction of the Cerebellar Flocculus.Cerebellum (London, England) · 2018Article
- A neurologist and ataxia: using eye movements to learn about the cerebellum.Cerebellum & ataxias · 2018Review
- Central Lesions With Selective Semicircular Canal Involvement Mimicking Bilateral Vestibulopathy.Frontiers in neurology · 2018Review
- The Video Head Impulse Test.Frontiers in neurology · 2017Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In spinocerebellar ataxia type 6 (SCA6), the vestibular dysfunction and its correlation with other clinical parameters require further exploration. We determined vestibular responses over a broad range of stimulus acceleration in 11 patients with SCA6 (six men, age range=33-72 years, mean age±SD=59±12 years) using bithermal caloric irrigations, rotary chair, and head impulse tests. Correlations were also pursued among disability scores, as measured using the International Cooperative Ataxia Rating Scale, disease duration, age at onset, cytosine-adenine-guanine (CAG) repeat length, and the gain of the vestibulo-ocular reflex (VOR). In response to relatively low-acceleration, low-frequency rotational and bithermal caloric stimuli, the VOR gains were normal or increased regardless of the severity of disease. On the other hand, with relatively high-acceleration, high-frequency head impulses, there was a relative increase in gain in the mildly affected patients and a decrease in gain in the more severely affected patients and gains were negatively correlated with the severity of disease (Spearman correlation, R=-0.927, p<0.001). Selective decrease of the vestibular responses during high-acceleration, high-frequency stimuli may be ascribed to degeneration of either the flocculus or vestibular nuclei. The performance of the VOR during high-acceleration, high-frequency head impulses may be a quantitative indicator of clinical decline in SCA6.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.