ArticleEndocrine connections2015
Visceral obesity is associated with increased soluble CD163 concentration in men with type 2 diabetes mellitus.
Article in Endocrine connections, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Soluble CD163 correlates with lipid metabolic adaptations in type 1 diabetes patients during ketoacidosis.Journal of diabetes investigation · 2019Trial
- Helminth infection induces RELMα-dependent adipose tissue transcriptional reprogramming and protection against diet-induced obesity.bioRxiv : the preprint server for biology · 2026Article
- Insulin Resistance and Inflammation.International journal of molecular sciences · 2026Review
- Characterization of Visceral Adipose Tissue Proteome Reveals Metabolic Changes and Inflammatory Signatures in Severe Obesity.Obesity (Silver Spring, Md.) · 2026Article
- Soluble CD163 is a predictor of fibrosis and hepatocellular carcinoma development in nonalcoholic steatohepatitis.BMC gastroenterology · 2023Article
- Insulin resistance is linked to a specific profile of immune activation in human subjects.Scientific reports · 2021Article
- Obesity-associated T-cell and macrophage activation improve partly after a lifestyle intervention.International journal of obesity (2005) · 2020Article
- Circulating betatrophin/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance but not those with glucose disorders.BMC endocrine disorders · 2020Article
- The Macrophage Activation Marker Soluble CD163 is Longitudinally Associated With Insulin Sensitivity and β-cell Function.The Journal of clinical endocrinology and metabolism · 2020Observational
- Systemic, but not local, low-grade endotoxinemia increases plasma sCD163 independently of the cortisol response.Endocrine connections · 2019Article
- Proteins Altered by Surgical Weight Loss Highlight Biomarkers of Insulin Resistance in the Community.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Macrophage activation marker sCD163 correlates with accelerated lipolysis following LPS exposure: a human-randomised clinical trial.Endocrine connections · 2018Article
- Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors.Molecular metabolism · 2017Article
- Higher CD163 levels are associated with insulin resistance in hepatitis C virus-infected and HIV-infected adults.AIDS (London, England) · 2017Article
- The Association between Monocyte Surface CD163 and Insulin Resistance in Patients with Type 2 Diabetes.Journal of diabetes research · 2017Article
- Cytokine expression in the visceral adipose tissue after laparoscopic and conventional surgery in a rodent model.European journal of medical research · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monocyte/macrophage-specific soluble CD163 (sCD163) concentration is associated with insulin resistance and increases with deteriorating glycemic control independently of BMI. This led to the proposal of the hypothesis that obesity-associated white adipose tissue inflammation varies between individuals. The objective was to examine the effect of male overweight/obesity and type 2 diabetes mellitus (T2DM) on associations between adiposity parameters and sCD163. A total of 23 overweight/obese non-diabetic men, 16 overweight/obese men with T2DM, and a control group of 20 normal-weight healthy men were included. Body composition and regional body fat distribution were determined by whole-body dual X-ray absorptiometry scan and abdominal computed tomography (CT) scan. Serum sCD163 concentrations were determined by ELISA. Associations between adiposity parameters and sCD163 were investigated using multiple linear regression analysis. In the normal-weight healthy men, there was no significant association between adiposity parameters and sCD163, whereas in the overweight/obese non-diabetic men, measures of general and regional adiposity were positively associated with sCD163. In the overweight/obese men with T2DM, only visceral adipose tissue (VAT) and the ratio of VAT to abdominal subcutaneous adipose tissue (SAT), a measure of relative body fat distribution between VAT and SAT depots, were positively associated with sCD163. In a multivariate analysis, including VAT, upper-body SAT, and lower-body fat, adjusted for BMI and age, VAT remained a significant predictor of sCD163 in the overweight/obese T2DM men, but not in the overweight/obese non-diabetic men. Our results indicate that VAT inflammation is exaggerated in men with T2DM, and that propensity to store excess body fat viscerally is particularly detrimental in men with T2DM.
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