Evidence map›Paper›PMID 25624071›Full record

ArticleArthritis care & research2015

Racial and Ethnic Differences in Mortality and Cardiovascular Events Among Patients With End-Stage Renal Disease Due to Lupus Nephritis.

Jose A Gómez-Puerta, Candace H Feldman, Graciela S Alarcón, Hongshu Guan, Wolfgang C Winkelmayer, Karen H Costenbader

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis care & research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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  13. Cardiovascular Implications of Immune Disorders in Women.Circulation research · 2022 · on this map
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  20. CKD and ESRD in US Hispanics.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jose A Gómez-PuertaBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Candace H FeldmanBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Graciela S AlarcónUniversity of Alabama at Birmingham.
Hongshu GuanBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Wolfgang C WinkelmayerBaylor College of Medicine, Houston, Texas.
Karen H CostenbaderBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Brigham and Women's Hospital · USHarvard University · USBaylor College of Medicine · USUniversity of Alabama at Birmingham · US

Funding

Sociodemographic Disparities in SLE Incidence: Behavioral and Psychosocial FactorsR01AR057327 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI COSTENBADER, KAREN H · 2009 to 2019
$6.2M
Cardiovascular Disease Epidemiology in Patients with LupusK24AR066109 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI COSTENBADER, KAREN H · 2014 to 2023
$1.7M
NIAMS NIH HHS K24 AR066109NIAMS NIH HHS K24-AR-066109NIAMS NIH HHS R01 AR057327NIAMS NIH HHS R01-AR-057327
6 · The paper itself

Abstract

objectiveTo identify racial and ethnic differences in mortality and cardiovascular (CV) risk among patients with end-stage renal disease (ESRD) due to lupus nephritis (LN).

methodsWithin the US ESRD registry (1995-2008), we identified individuals ages >17 years with incident ESRD due to systemic lupus erythematosus. We ascertained demographics, clinical factors, and deaths from registry patient files and CV events (myocardial infarction, heart failure, and hemorrhagic and ischemic strokes) from inpatient Medicare claims. We calculated incidence rates (95% confidence intervals [95% CIs]) per 1,000 person-years for study events, stratified by race and ethnicity. We compared probabilities of the events among racial and ethnic groups using cumulative incidence function curves and multivariable-adjusted subdistribution proportional hazard ratios (HRsd), taking into account the competing events of kidney transplantation and death (for nonfatal CV events).

resultsOf 12,533 patients with LN-associated ESRD, the mean ± SD age was 40.7 ± 14.9 years, 82% were women, and 49% were African American. The overall mortality rate was 98.1/1,000 person-years (95% CI 95.3-100.9). In multivariable models, Asian and Hispanic LN-associated ESRD patients had lower mortality than whites (HRsd 0.70 [95% CI 0.58-0.84] and 0.79 [95% CI 0.71-0.88], respectively), whereas African Americans had higher mortality (HRsd 1.27 [95% CI 1.18-1.36]). African American patients >40 years old had higher mortality than their white counterparts (HRsd 1.67 [95% CI 1.44-1.93]). African Americans were more likely to be admitted for heart failure or hemorrhagic stroke.

conclusionAmong patients with LN-associated ESRD, Asians and Hispanics experienced lower mortality and CV event risks than whites, and African Americans had higher mortality and CV event risks than whites.

Indexed as

Cause of DeathAdultAge FactorsCardiovascular DiseasesCohort StudiesConfidence IntervalsEthnicityFemaleHumansKidney Failure, ChronicLupus NephritisMaleMiddle AgedPrognosisRacial GroupsRegistries

Identifiers

PMID25624071
PMCPMC4515402
OpenAlexW2130979196

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.