ArticleOsteoarthritis and cartilage2015
Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat.
Article in Osteoarthritis and cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Three-dimensional visualization of nerves in bones of the human hand in osteoarthritis.JBMR plus · 2026Article
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- Experimental models to study osteoarthritis pain and develop therapeutics.Osteoarthritis and cartilage open · 2022Review
- NGF Expression and Elevation in Hip Osteoarthritis Patients with Pain and Central Sensitization.BioMed research international · 2021Article
- Intra-articular delivery of flurbiprofen sustained release thermogel: improved therapeutic outcome of collagenase II-induced rat knee osteoarthritis.Drug delivery · 2020Article
- Targeting neurotrophic factors: Novel approaches to musculoskeletal pain.Pharmacology & therapeutics · 2020Review
- Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain.The Journal of clinical investigation · 2019Article
- Intra-articular Recombinant Human Growth Hormone Injection Compared with Hyaluronic Acid and Placebo for an Osteoarthritis Model of New Zealand Rabbits.Knee surgery & related research · 2019Article
- Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA).Osteoarthritis and cartilage · 2016Article
- Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models.Journal of neuroinflammation · 2016Article
- The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain.Osteoarthritis and cartilage · 2016Article
- Article
- The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain.Current osteoporosis reports · 2015Review
- Peripheral mechanisms of arthritic pain: A proposal to leverage large animals forNeurobiology of pain (Cambridge, Mass.)Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAlthough analgesic approaches targeting nerve growth factor (NGF) for the treatment of osteoarthritis (OA) pain remain of clinical interest, neurophysiological mechanisms by which NGF contribute to OA pain remain unclear. We investigated the impact of local elevation of knee joint NGF on knee joint, vs remote (hindpaw), evoked responses of spinal neurones in a rodent model of OA pain.
designIn vivo spinal electrophysiology was carried out in anaesthetised rats with established pain behaviour and joint pathology following intra-articular injection of monosodium iodoacetate (MIA), vs injection of saline. Neuronal responses to knee joint extension and flexion, mechanical punctate stimulation of the peripheral receptive fields over the knee and at a remote site (ipsilateral hind paw) were studied before, and following, intra-articular injection of NGF (10 μg/50 μl) or saline.
resultsMIA-injected rats exhibited significant local (knee joint) and remote (lowered hindpaw withdrawal thresholds) changes in pain behaviour, and joint pathology. Intra-articular injection of NGF significantly (P < 0.05) increased knee extension-evoked firing of spinal neurones and the size of the peripheral receptive fields of spinal neurones (100% increase) over the knee joint in MIA rats, compared to controls. Intra-articular NGF injection did not significantly alter responses of spinal neurones following noxious stimulation of the ipsilateral hind paw in MIA-injected rats.
conclusionThe facilitatory effects of intra-articular injection of NGF on spinal neurones receiving input from the knee joint provide a mechanistic basis for NGF mediated augmentation of OA knee pain, however additional mechanisms may contribute to the spread of pain to remote sites.
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