ArticleGlobal health action2015
Poverty-related and neglected diseases - an economic and epidemiological analysis of poverty relatedness and neglect in research and development.
Article in Global health action, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The importance of long-term studies in children following viral infection of the central nervous system.EClinicalMedicine · 2025Review
- Socially responsible science: Exploring the complexities.European journal for philosophy of science · 2023Article
- Investing in a global pooled-funding mechanism for late-stage clinical trials of poverty-related and neglected diseases: an economic evaluation.BMJ global health · 2023Article
- Does health-related poverty publication landscape reflect global needs in the light of the current poverty rebound?Globalization and health · 2022Article
- Ethical Machine Learning in Healthcare.Annual review of biomedical data science · 2021Article
- Exploring why global health needs are unmet by research efforts: the potential influences of geography, industry and publication incentives.Health research policy and systems · 2020Article
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- Where is the 'global' in the European Union's Health Research and Innovation Agenda?BMJ global health · 2019Review
- Quantifying changes in global health inequality: the Gini and Slope Inequality Indices applied to the Global Burden of Disease data, 1990-2017.BMJ global health · 2019Article
- Antibiotic Use in Agriculture and Its Consequential Resistance in Environmental Sources: Potential Public Health Implications.Molecules (Basel, Switzerland) · 2018Review
- Justifiability and Animal Research in Health: Can Democratisation Help Resolve Difficulties?Animals : an open access journal from MDPI · 2018Review
- Poverty-related diseases (PRDs): unravelling complexities in disease responses in Cameroon.Tropical medicine and health · 2017Article
- NEIGHBOURHOOD POVERTY, PERCEIVED DISCRIMINATION AND CENTRAL ADIPOSITY IN THE USA: INDEPENDENT ASSOCIATIONS IN A REPEATED MEASURES ANALYSIS.Journal of biosocial science · 2016Article
- Global health equity in United Kingdom university research: a landscape of current policies and practices.Health research policy and systems · 2016Article
- Poverty-Related Diseases College: a virtual African-European network to build research capacity.BMJ global health · 2016Article
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEconomic growth in low- and middle-income countries (LMIC) has raised interest in how disease burden patterns are related to economic development. Meanwhile, poverty-related diseases are considered to be neglected in terms of research and development (R&D).
objectivesDeveloping intuitive and meaningful metrics to measure how different diseases are related to poverty and neglected in the current R&D system.
designWe measured how diseases are related to economic development with the income relation factor (IRF), defined by the ratio of disability-adjusted life-years (DALYs) per 100,000 inhabitants in LMIC versus that in high-income countries. We calculated the IRF for 291 diseases and injuries and 67 risk factors included in the Global Burden of Disease Study 2010. We measured neglect in R&D with the neglect factor (NF), defined by the ratio of disease burden in DALYs (as percentage of the total global disease burden) and R&D expenditure (as percentage of total global health-related R&D expenditure) for 26 diseases.
resultsThe disease burden varies considerably with the level of economic development, shown by the IRF (median: 1.38; interquartile range (IQR): 0.79-6.3). Comparison of IRFs from 1990 to 2010 highlights general patterns of the global epidemiological transition. The 26 poverty-related diseases included in our analysis of neglect in R&D are responsible for 13.8% of the global disease burden, but receive only 1.34% of global health-related R&D expenditure. Within this group, the NF varies considerably (median: 19; IQR: 6-52).
conclusionsThe IRF is an intuitive and meaningful metric to highlight shifts in global disease burden patterns. A large shortfall exists in global R&D spending for poverty-related and neglected diseases, with strong variations between diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.