Evidence map›Paper›PMID 25623244›Full record

SynthesisMultiple sclerosis (Houndmills, Basingstoke, England)2015

A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview.

Ruth Ann Marrie, Jeffrey Cohen, Olaf Stuve, Maria Trojano, Per Soelberg Sørensen, Stephen Reingold, Gary Cutter, Nadia Reider

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Multiple sclerosis (Houndmills, Basingstoke, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05382195 (Clinical Correlates of Psychiatric Comorbidities in Patients With Multiple Sclerosis), which is not on this map. Cited by 190 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 16 pooled it
21.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05382195 unknown statusnot on this mapstarted 2022, after this paper: background citation

Clinical Correlates of Psychiatric Comorbidities in Patients With Multiple Sclerosis

TypeobservationalSponsorSohag UniversityRan2022 to 2023Enrolled100ConditionsPatients With Multiple SclerosisArmshospital anxiety and depression scale
3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 16 syntheses or guidelines pooled it, 396 citations in OpenAlex.

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  15. A systematic review of the incidence and prevalence of cancer in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2015
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  20. Association of serum homocysteine, folate, and vitamin BMultiple sclerosis and related disorders · 2023
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130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Ruth Ann MarrieDepartment of Internal Medicine, University of Manitoba, Canada/Department of Community Health Sciences, University of Manitoba, Health Sciences Center, Canada rmarrie@hsc.mb.ca.
Jeffrey CohenMellen Center for MS Treatment and Research, Cleveland Clinic, USA.
Olaf StuveDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern, USA.
Maria TrojanoDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Italy.
Per Soelberg SørensenDepartment of Neurology, Copenhagen University Hospital Rigshospitalet, Denmark.
Stephen ReingoldScientific and Clinical Review Associates, LLC, USA.
Gary CutterDepartment of Biostatistics, University of Alabama at Birmingham, USA.
Nadia ReiderDepartment of Internal Medicine, University of Manitoba, Canada.
University of Manitoba · CACleveland Clinic · USRigshospitalet · DKThe University of Texas Southwestern Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Bari Aldo Moro · IT

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

backgroundComorbidity is an area of increasing interest in multiple sclerosis (MS).

objectiveThe objective of this review is to estimate the incidence and prevalence of comorbidity in people with MS and assess the quality of included studies.

methodsWe searched the PubMed, SCOPUS, EMBASE and Web of Knowledge databases, conference proceedings, and reference lists of retrieved articles. Two reviewers independently screened abstracts. One reviewer abstracted data using a standardized form and the abstraction was verified by a second reviewer. We assessed study quality using a standardized approach. We quantitatively assessed population-based studies using the I² statistic, and conducted random-effects meta-analyses.

resultsWe included 249 articles. Study designs were variable with respect to source populations, case definitions, methods of ascertainment and approaches to reporting findings. Prevalence was reported more frequently than incidence; estimates for prevalence and incidence varied substantially for all conditions. Heterogeneity was high.

conclusionThis review highlights substantial gaps in the epidemiological knowledge of comorbidity in MS worldwide. Little is known about comorbidity in Central or South America, Asia or Africa. Findings in North America and Europe are inconsistent. Future studies should report age-, sex- and ethnicity-specific estimates of incidence and prevalence, and standardize findings to a common population.

Indexed as

ComorbidityHumansIncidenceMultiple SclerosisPrevalencecomorbidityincidenceMultiple sclerosisprevalencesystematic review

Identifiers

PMID25623244
PMCPMC4361468
OpenAlexW2159596132

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.