ArticleBMC genomics2015
Genomic and transcriptomic analysis of the endophytic fungus Pestalotiopsis fici reveals its lifestyle and high potential for synthesis of natural products.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed.
- Draft genome sequence ofMicrobiology resource announcements · 2026Article
- Plant recognition by Trichoderma Harzianum elicits upregulation of a novel secondary metabolite cluster required for colonization.Scientific reports · 2026Article
- Genomic and metabolic uniformity across diverse observed ecological contexts suggest that interactions ofIMA fungus · 2026Article
- Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi.Angewandte Chemie (International ed. in English) · 2025Article
- How genomics can help unravel the evolution of endophytic fungi.World journal of microbiology & biotechnology · 2025Review
- Cloning and expression of theFrontiers in microbiology · 2025Article
- Complete genome sequence analysis of Pestalotiopsis microspora, a fungal pathogen causing kiwifruit postharvest rots.BMC genomics · 2024Article
- Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms.Antibiotics (Basel, Switzerland) · 2024Review
- Incorporating omics-based tools into endophytic fungal research.Biotechnology notes (Amsterdam, Netherlands) · 2024Review
- Endophytic strategies decoded by genome and transcriptome analysis ofFrontiers in microbiology · 2024Article
- Phylogenomics, taxonomy and morphological characters of the Microdochiaceae (Xylariales, Sordariomycetes).MycoKeys · 2024Article
- Exploring the potential of endophyte-plant interactions for improving crop sustainable yields in a changing climate.Frontiers in plant science · 2024Review
- Genomic Characterization of the MycoparasitePolish journal of microbiology · 2023Article
- Fungal secondary metabolism is governed by an RNA-binding protein CsdA/RsdA complex.Nature communications · 2023Article
- Current status of research on endophytes of traditional Tibetan medicinal plant and their metabolites.3 Biotech · 2023Review
- Review
- Identification, Culture Characteristics and Whole-Genome Analysis ofJournal of fungi (Basel, Switzerland) · 2023Article
- A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin.Nature communications · 2022Article
- Characterization of a NRPS-like Protein fromJournal of fungi (Basel, Switzerland) · 2022Article
- Combatting insects mediated biotic stress through plant associated endophytic entomopathogenic fungi in horticultural crops.Frontiers in plant science · 2022Review
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15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, the genus Pestalotiopsis is receiving increasing attention, not only because of its economic impact as a plant pathogen but also as a commonly isolated endophyte which is an important source of bioactive natural products. Pestalotiopsis fici Steyaert W106-1/CGMCC3.15140 as an endophyte of tea produces numerous novel secondary metabolites, including chloropupukeananin, a derivative of chlorinated pupukeanane that is first discovered in fungi. Some of them might be important as the drug leads for future pharmaceutics.
resultsHere, we report the genome sequence of the endophytic fungus of tea Pestalotiopsis fici W106-1/CGMCC3.15140. The abundant carbohydrate-active enzymes especially significantly expanding pectinases allow the fungus to utilize the limited intercellular nutrients within the host plants, suggesting adaptation of the fungus to endophytic lifestyle. The P. fici genome encodes a rich set of secondary metabolite synthesis genes, including 27 polyketide synthases (PKSs), 12 non-ribosomal peptide synthases (NRPSs), five dimethylallyl tryptophan synthases, four putative PKS-like enzymes, 15 putative NRPS-like enzymes, 15 terpenoid synthases, seven terpenoid cyclases, seven fatty-acid synthases, and five hybrids of PKS-NRPS. The majority of these core enzymes distributed into 74 secondary metabolite clusters. The putative Diels-Alderase genes have undergone expansion.
conclusionThe significant expansion of pectinase encoding genes provides essential insight in the life strategy of endophytes, and richness of gene clusters for secondary metabolites reveals high potential of natural products of endophytic fungi.
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