ArticleJournal of gastroenterology2015
Helicobacter pylori infection might have a potential role in hepatocyte ballooning in nonalcoholic fatty liver disease.
Article in Journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Pooled it
- Relationship ofCanadian journal of gastroenterology & hepatology · 2023Pooled it
- Association between Helicobacter pylori infection and non-alcoholic fatty liver disease for Asian and non-Asian population: A systematic review and meta-analysis.Frontiers in public health · 2022Pooled it
- Association between Helicobacter pylori infection and nonalcoholic fatty liver: A meta-analysis.Medicine · 2019Pooled it
- Helicobacter pylori infection eradication for nonalcoholic fatty liver disease: a randomized controlled trial.Scientific reports · 2022Trial
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- Depression symptoms in perimenopausal women with somatic pain: nomogram construction based on a logistic regression model.Frontiers in public health · 2025Article
- Detection of H-Pylori in the Explanted Liver Tissue and the Enlarged Perihepatic Lymph Nodes of Cirrhotic Patients with Decompensated End-Stage Liver Disease Recruited for Liver Transplantation.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Is Helicobacter pylori infection a risk factor for non-alcoholic fatty liver disease in children?European journal of pediatrics · 2024Article
- Association between Helicobacter pylori infection, MASLD, and liver fibrosis in patients with severe obesity: a single-center experience.Surgical endoscopy · 2024Article
- Prevalence and risk factors associated with metabolic dysfunction-associated steatohepatitis in patients withWorld journal of hepatology · 2024Article
- The possible role of Helicobacter pylori in liver diseases.Archives of microbiology · 2023Review
- Impact ofJournal of clinical and translational hepatology · 2023Review
- The Effects ofBioMed research international · 2023Article
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- Total Flavonoids fromFoods (Basel, Switzerland) · 2022Article
- Helicobacter pylori infection is not an independent risk factor of non-alcoholic fatty liver disease in China.BMC gastroenterology · 2022Article
Corrections and comments
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Authors and funding
21 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical data regarding Helicobacter pylori (H. pylori) infection in nonalcoholic fatty liver disease (NAFLD) are limited. The aim was to evaluate H. pylori infection in patients with NAFLD and its association with disease severity.
methodsOne hundred and thirty patients with biopsy-proven NAFLD [43 with nonalcoholic fatty liver (NAFL) and 87 with nonalcoholic steatohepatitis (NASH)] were recruited for blood samples for anti-H. pylori immunoglobulin G (IgG) and standard biochemical tests were obtained after overnight fasting. Glucose tolerance was evaluated by 75-g oral glucose tolerance test. Liver biopsies were scored for NAFLD activity score (NAS), fibrosis and iron deposits.
resultsH. pylori IgG seropositivity was found in 40 % of patients overall. The prevalence of NASH was significantly higher in the patients with H. pylori IgG seropositivity (81 %) than in those without (58 %, p = 0.008). Glucose intolerance was similar between the two groups. The total NAS and the grade of hepatocyte ballooning were higher in the patients with H. pylori IgG seropositivity than in those without, while the hepatic iron grade was lower in the patients with H. pylori IgG seropositivity than in those without. H. pylori infection (p = 0.030), female gender (p = 0.029), and NAFIC score ≥ 2 points (p < 0.001) could independently predict NASH in logistic regression analysis, independent of age, obesity and glucose tolerance.
conclusionThe association of H. pylori seropositivity with hepatocyte ballooning suggests that H. pylori infection may represent another contributing factor in the progression from NAFL to NASH. Eradicating H. pylori infection may have therapeutic prospects in NASH treatment.
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