Evidence map›Paper›PMID 25622848›Full record

ReviewNature reviews. Cardiology2015

Inflammation and the pathogenesis of atrial fibrillation.

Yu-Feng Hu, Yi-Jen Chen, Yenn-Jiang Lin, Shih-Ann Chen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 661 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
661citing papers in PubMed, 6 pooled it
34.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

661 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,039 citations in OpenAlex.

  1. Pooled it
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  5. Effects of colchicine on the prevention of AF recurrence after atrial ablation: a systematic review and meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024
    Pooled it
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  7. Inflammation and day-to-day occurrence of atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
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  12. Molecular phenotyping of atrial remodeling in atrial fibrillation usingThe international journal of cardiovascular imaging · 2026
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601 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yu-Feng HuDivision of Cardiology, Department of Medicine, Taipei Veterans General Hospital, National Yang-Ming University, Number 201, Section 2, Shipai Road, Beitou District, Taipei 11217, Taiwan, Republic of China.
Yi-Jen ChenDivision of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Number 111, Section 3, Hsing-Long Road, Taipei 11696, Taiwan, Republic of China.
Yenn-Jiang LinDivision of Cardiology, Department of Medicine, Taipei Veterans General Hospital, National Yang-Ming University, Number 201, Section 2, Shipai Road, Beitou District, Taipei 11217, Taiwan, Republic of China.
Shih-Ann ChenDivision of Cardiology, Department of Medicine, Taipei Veterans General Hospital, National Yang-Ming University, Number 201, Section 2, Shipai Road, Beitou District, Taipei 11217, Taiwan, Republic of China.
National Yang Ming Chiao Tung University · TWWan Fang Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most common cardiac arrhythmia. However, the development of preventative therapies for AF has been disappointing. The infiltration of immune cells and proteins that mediate the inflammatory response in cardiac tissue and circulatory processes is associated with AF. Furthermore, the presence of inflammation in the heart or systemic circulation can predict the onset of AF and recurrence in the general population, as well as in patients after cardiac surgery, cardioversion, and catheter ablation. Mediators of the inflammatory response can alter atrial electrophysiology and structural substrates, thereby leading to increased vulnerability to AF. Inflammation also modulates calcium homeostasis and connexins, which are associated with triggers of AF and heterogeneous atrial conduction. Myolysis, cardiomyocyte apoptosis, and the activation of fibrotic pathways via fibroblasts, transforming growth factor-β and matrix metalloproteases are also mediated by inflammatory pathways, which can all contribute to structural remodelling of the atria. The development of thromboembolism, a detrimental complication of AF, is also associated with inflammatory activity. Understanding the complex pathophysiological processes and dynamic changes of AF-associated inflammation might help to identify specific anti-inflammatory strategies for the prevention of AF.

Indexed as

Anti-Inflammatory AgentsAtrial FibrillationAutoimmunityCardiac Surgical ProceduresCatheter AblationCoronary Artery DiseaseCytokinesHumansHypertensionInflammationInflammation MediatorsObesityVentricular RemodelingAnti-Inflammatory AgentsCytokinesInflammation Mediators

Identifiers

PMID25622848
OpenAlexW2071675848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.