Trial reportDrug and alcohol dependence2015
Using behavioral economics to predict opioid use during prescription opioid dependence treatment.
Trial report in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Measurement of substance-free reinforcement in addiction: A systematic review.Clinical psychology review · 2019Pooled it
- Behavioral economic predictors of brief alcohol intervention outcomes.Journal of consulting and clinical psychology · 2015Trial
- Preferences and predictors driving opioid-involved polysubstance use profiles and trajectories: a prospective cohort study protocol.BMJ open · 2025Article
- A hypothetical lottery task to assess relative resource allocation toward alcohol and cannabis.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023Article
- Behavioral economic indicators of risky drinking among community-dwelling emerging adults.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021Article
- The role of reward and reinforcement in understanding alcohol use among adults living with HIV in South Africa.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021Article
- Shifts in behavioral allocation patterns as a natural recovery mechanism: Postresolution expenditure patterns.Alcoholism, clinical and experimental research · 2021Article
- Behavioral predictors of individual differences in opioid addiction vulnerability as measured using i.v. self-administration in rats.Drug and alcohol dependence · 2021Review
- Individual Differences in Different Measures of Opioid Self-Administration in Rats Are Accounted for by a Single Latent Variable.Frontiers in psychiatry · 2021Article
- Higher anhedonia during withdrawal from initial opioid exposure is protective against subsequent opioid self-administration in rats.Psychopharmacology · 2020Article
- Preresolution Drinking Problem Severity Profiles Associated with Stable Moderation Outcomes of Natural Recovery Attempts.Alcoholism, clinical and experimental research · 2020Article
- Changes in fentanyl demand following naltrexone, morphine, and buprenorphine in male rats.Drug and alcohol dependence · 2020Article
- Environmental enrichment and drug value: a behavioral economic analysis in male rats.Addiction biology · 2019Article
- Prospective Analysis of Behavioral Economic Predictors of Stable Moderation Drinking Among Problem Drinkers Attempting Natural Recovery.Alcoholism, clinical and experimental research · 2016Article
- Behavioral economic indicators of drinking problem severity and initial outcomes among problem drinkers attempting natural recovery: a cross-sectional naturalistic study.Addiction (Abingdon, England) · 2016Observational
- Sources of Prescription Medication Misuse Among Young Adults in the United States: The Role of Educational Status.The Journal of clinical psychiatryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundResearch grounded in behavioral economics has previously linked addictive behavior to disrupted decision-making and reward-processing, but these principles have not been examined in prescription opioid addiction, which is currently a major public health problem. This study examined whether pre-treatment drug reinforcement value predicted opioid use during outpatient treatment of prescription opioid addiction.
methodsSecondary analyses examined participants with prescription opioid dependence who received 12 weeks of buprenorphine-naloxone and counseling in a multi-site clinical trial (N=353). Baseline measures assessed opioid source and indices of drug reinforcement value, including the total amount and proportion of income spent on drugs. Weekly urine drug screens measured opioid use.
resultsObtaining opioids from doctors was associated with lower pre-treatment drug spending, while obtaining opioids from dealers/patients was associated with greater spending. Controlling for demographics, opioid use history, and opioid source frequency, patients who spent a greater total amount (OR=1.30, p<.001) and a greater proportion of their income on drugs (OR=1.31, p<.001) were more likely to use opioids during treatment.
conclusionsIndividual differences in drug reinforcement value, as indicated by pre-treatment allocation of economic resources to drugs, reflects propensity for continued opioid use during treatment among individuals with prescription opioid addiction. Future studies should examine disrupted decision-making and reward-processing in prescription opioid users more directly and test whether reinforcer pathology can be remediated in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.