ArticleJournal of nanobiotechnology2015
Micro CT visualization of silver nanoparticles in the middle and inner ear of rat and transportation pathway after transtympanic injection.
Article in Journal of nanobiotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Imaging of the Eustachian tube and its function: a systematic review.Neuroradiology · 2016Pooled it
- Engineered Inner Ear Drug Delivery Systems for Hearing Loss Treatment.Research (Washington, D.C.) · 2026Review
- Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Recent progress in cryoablation cancer therapy and nanoparticles mediated cryoablation.Theranostics · 2022Review
- Silver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo.Nanomaterials (Basel, Switzerland) · 2021Article
- Nanoparticles for the Treatment of Inner Ear Infections.Nanomaterials (Basel, Switzerland) · 2021Review
- Nanocarriers for Inner Ear Disease Therapy.Frontiers in cellular neuroscience · 2021Review
- Promising Applications of Nanoparticles in the Treatment of Hearing Loss.Frontiers in cell and developmental biology · 2021Review
- Contralateral spreading of substances following intratympanic nanoparticle-conjugated gentamicin injection in a rat model.Scientific reports · 2020Article
- New Look on Antifungal Activity of Silver Nanoparticles (AgNPs).Polish journal of microbiology · 2019Article
- Developments in Bio-Inspired Nanomaterials for Therapeutic Delivery to Treat Hearing Loss.Frontiers in cellular neuroscience · 2019Review
- In-Situ High Resolution Dynamic X-ray Microtomographic Imaging of Olive Oil Removal in Kitchen Sponges by Squeezing and Rinsing.Materials (Basel, Switzerland) · 2018Article
- Innovative pharmaceutical approaches for the management of inner ear disorders.Drug delivery and translational research · 2018Review
- Multi-scale X-ray computed tomography to detect and localize metal-based nanomaterials in lung tissues of in vivo exposed mice.Scientific reports · 2018Article
- Challenges and opportunities in developing targeted molecular imaging to determine inner ear defects of sensorineural hearing loss.Nanomedicine : nanotechnology, biology, and medicine · 2018Review
- Understanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine.International journal of nanomedicine · 2018Article
- Biocompatibility of Liposome Nanocarriers in the Rat Inner Ear After Intratympanic Administration.Nanoscale research letters · 2017Article
- Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies.Advanced drug delivery reviews · 2017Review
- Clinically relevant human temporal bone measurements using novel high-resolution cone-beam CT.Journal of otology · 2017Article
- Nanomedicine for Inner Ear Diseases: A Review of RecentBioMed research international · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSilver nanoparticles (Ag NPs) displayed strong activities in anti-bacterial, anti-viral, and anti-fungal studies and were reportedly efficient in treating otitis media. Information on distribution of AgNPs in different compartments of the ear is lacking.
objectiveTo detect distribution of Ag NPs in the middle and inner ear and transportation pathways after transtympanic injection.
methodsContrast effect of Ag NPs in the micro CT imaging was assessed in a phantom. AgNPs at various concentrations (1.85 mM, 37.1 mM, and 370.7 mM) were administered to rat middle ear using transtympanic injection and cadaver heads were imaged using micro CT at several time points.
resultsThe lowest concentration of Ag NPs that could be visualized using micro CT was 37.1 mM. No difference was observed between the solvents, deionized H2O and saline. Ag NPs at 37.1 mM were visible in the middle ear on 7 d post-administration. Ag NPs at 370.7 mM generated signals in the middle ear, ossicular chain, round window membrane, oval window, scala tympani, and Eustachian tube for both 4 h and 24 h time points. A gradient distribution of Ag NPs from the middle ear to the inner ear was detected. The pathways for Ag NPs to be transported from the middle ear into the inner ear are round and oval windows.
conclusionThis study provided the imaging evidence that Ag NPs are able to access the inner ear in a dose-dependent manner after intratympanic administration, which is relevant to design the delivery concentration in the future clinic application in order to avoid adverse inner ear effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.