Trial reportJournal of consulting and clinical psychology2015
Predicting meaningful outcomes to medication and self-help treatments for binge-eating disorder in primary care: The significance of early rapid response.
Trial report in Journal of consulting and clinical psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Binge Eating in Obese Patients in Primary Care
Do Visuals of Symptom Change Increase Rates of Rapid Response in First Weeks of CBT for Eating Disorders?
Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Rapid response to behavioral/pharmacological obesity treatments for binge-eating disorder predicts better clinical outcomes.Obesity (Silver Spring, Md.) · 2025Trial
- Change in impulsivity is prospectively associated with treatment outcomes for binge-eating disorder.Psychological medicine · 2023Trial
- Predictors and significance of rapid response to behaviorally based treatment of binge eating disorder.Obesity (Silver Spring, Md.) · 2023Trial
- Rapid response is predictive of treatment outcomes in a transdiagnostic intensive outpatient eating disorder sample: a replication of prior research in a real-world setting.Eating and weight disorders : EWD · 2021Trial
- Randomized Controlled Trial of Behavioral Weight Loss and Stepped Care for Binge-Eating Disorder: 12-Month Follow-up.Obesity (Silver Spring, Md.) · 2020Trial
- Early Symptom Trajectories as Predictors of Treatment Outcome for Citalopram Versus Placebo.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Trial
- An adaptive randomized trial of dialectical behavior therapy and cognitive behavior therapy for binge-eating.Psychological medicine · 2017Trial
- Randomized controlled trial testing the effectiveness of adaptive "SMART" stepped-care treatment for adults with binge-eating disorder comorbid with obesity.The American psychologistTrial
- Lisdexamfetamine maintenance treatment for binge-eating disorder following successful treatments: randomized double-blind placebo-controlled trial.Psychological medicine · 2024Article
- Pharmacotherapy, alternative and adjunctive therapies for eating disorders: findings from a rapid review.Journal of eating disorders · 2023Review
- Features of Addiction in Binge-Eating Disorder: Considerations for Screening and Treatment.Substance abuse and rehabilitation · 2023Review
- Can early change in eating disorder psychopathology predict outcome in guided self-help for binge eating?Eating and weight disorders : EWD · 2021Article
- Clinical moderators and predictors of cognitive-behavioral therapy by guided-self-help versus therapist-led for binge-eating disorder: Analysis of aggregated clinical trials.The International journal of eating disorders · 2021Article
- Psychotherapy and Medications for Eating Disorders: Better Together?Clinical therapeutics · 2021Review
- New Horizons in Measurement: a Review of Novel and Innovative Approaches to Eating-Disorder Assessment.Current psychiatry reports · 2017Review
- Pharmacological treatment of binge eating disorder: update review and synthesis.Expert opinion on pharmacotherapy · 2015Review
- Women Veterans' Treatment Preferences for Disordered Eating.Women's health issues : official publication of the Jacobs Institute of Women's HealthArticle
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe examined rapid response among obese patients with binge-eating disorder (BED) in a randomized clinical trial testing antiobesity medication and self-help cognitive-behavioral therapy (shCBT), alone and in combination, in primary-care settings.
methodOne hundred four obese patients with BED were randomly assigned to 1 of 4 treatments: sibutramine, placebo, shCBT + sibutramine, or shCBT + placebo. Treatments were delivered by generalist primary-care physicians and the medications were given double-blind. Independent assessments were performed by trained and monitored doctoral research clinicians monthly throughout treatment, posttreatment (4 months), and at 6- and 12-month follow-ups (i.e., 16 months after randomization). Rapid response, defined as ≥65% reduction in binge eating by the fourth treatment week, was used to predict outcomes.
resultsRapid response characterized 47% of patients, was unrelated to demographic and baseline clinical characteristics, and was significantly associated, prospectively, with remission from binge eating at posttreatment (51% vs. 9% for nonrapid responders), 6-month (53% vs. 23.6%), and 12-month (46.9% vs. 23.6%) follow-ups. Mixed-effects model analyses revealed that rapid response was significantly associated with greater decreases in binge-eating or eating-disorder psychopathology, depression, and percent weight loss. DISCUSSION: Our findings, based on a diverse obese patient group receiving medication and shCBT for BED in primary-care settings, indicate that patients who have a rapid response achieve good clinical outcomes through 12-month follow-ups after ending treatment. Rapid response represents a strong prognostic indicator of clinically meaningful outcomes, even in low-intensity medication and self-help interventions. Rapid response has important clinical implications for stepped-care treatment models for BED. CLINICAL
trial registrationclinicaltrials.gov: NCT00537810 (PsycINFO Database Record
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.