ArticleOncotarget2015
Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNA-binding protein and a p53 family target, via mRNA translation.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- TRIM21-driven K63-linked ubiquitination of RBM38c, as a novel interactor of BECN1, contributes to DNA damage-induced autophagy.Cell death and differentiation · 2025Article
- RBM22, a Key Player of Pre-mRNA Splicing and Gene Expression Regulation, Is Altered in Cancer.Cancers · 2022Review
- Using weighted gene co-expression network analysis (WGCNA) to identify the hub genes related to hypoxic adaptation in yak (Bos grunniens).Genes & genomics · 2021Article
- RBM38 in cancer: role and mechanism.Cellular and molecular life sciences : CMLS · 2021Review
- miR129-1 regulates protein phosphatase 1D protein expression under hypoxic conditions in non-small cell lung cancer cells harboring a TP53 mutation.Oncology letters · 2020Article
- The Effect of MicroRNA-101 on Angiogenesis of Human Umbilical Vein Endothelial Cells during Hypoxia and in Mice with Myocardial Infarction.BioMed research international · 2020Article
- Activation of Hypoxia-Inducible Factor Signaling Modulates the RNA Protein Interactome in Caenorhabditis elegans.iScience · 2019Article
- Cancer the'RBP'eutics-RNA-binding proteins as therapeutic targets for cancer.Pharmacology & therapeutics · 2019Review
- Therapeutic modulation of RNA-binding protein Rbm38 facilitates re-endothelialization after arterial injury.Cardiovascular research · 2019Article
- The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells.Journal of the American Society of Nephrology : JASN · 2019Article
- Translating the Hypoxic Response-the Role of HIF Protein Translation in the Cellular Response to Low Oxygen.Cells · 2019Review
- Comparative genomic investigation of high-elevation adaptation in ectothermic snakes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- 40 Years of Research Put p53 in Translation.Cancers · 2018Review
- Role of HIF-1α and CASPASE-3 in cystogenesis of odontogenic cysts and tumors.Clinical oral investigations · 2018Article
- RBM38 is involved in TGF-β-induced epithelial-to-mesenchymal transition by stabilising zonula occludens-1 mRNA in breast cancer.British journal of cancer · 2017Article
- The RNA-binding protein Rbm38 is dispensable during pressure overload-induced cardiac remodeling in mice.PloS one · 2017Article
- KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation.Development (Cambridge, England) · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Hypoxia-inducible factor 1 (HIF1), a heterodimeric transcription factor, consists of HIF1α and HIF1β and is necessary for cell growth and survival under a hypoxic condition. Thus, the level and activity of HIF1α needs to be tightly controlled. Indeed, HIF1α protein stability is controlled by prolyl hydroxylase and von Hippel-Lindau-mediated proteosomal degradation. However, it remains unclear whether HIF1α expression is controlled by other pathways. Here, we showed that RNA-binding protein RBM38, a target of the p53 family, regulates HIF1α expression via mRNA translation. Specifically, we showed that under a hypoxic condition, ectopic expression of RBM38 decreased, whereas knockdown of RBM38 increased, the level of HIF1α protein. We also showed that the rate of de novo HIF1α protein synthesis was increased by knockdown of RBM38. Additionally, we showed that RBM38 directly bound to HIF1α 5' and 3'UTRs. Consistently, we showed that the rate of mRNA translation for a heterologous reporter that carries HIF1α 5'and/or 3'UTRs was increased upon knockdown of RBM38. Furthermore, we showed that knockdown of RBM38 increased, whereas ectopic expression of RBM38 decreased, the binding of eIF4E to HIF1α mRNA. Together, our data suggest that RBM38 is a novel translational regulator of HIF1α under a hypoxic condition.
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