Observational studyJAMA neurology2015
Factors associated with the onset and persistence of post-lumbar puncture headache.
Observational study in JAMA neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Systematic Review of miRNA as Biomarkers in Alzheimer's Disease.Molecular neurobiology · 2019Pooled it
- Non-Invasive Intracranial Pressure Waveform Assessment as a Screening Test for Abnormal Lumbar Puncture Results.European journal of neurology · 2026Article
- Schizophrenia Spectrum Biomarkers Consortium: Establishment of a Biorepository for the Discovery of Quantitative Fluid Biomarkers.Schizophrenia bulletin · 2026Article
- Predictors of post-lumbar puncture headache in an academic outpatient neurology setting: a retrospective exploratory study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Protocol to avoid post-dural puncture headache after large-volume cerebral spinal fluid extraction in a prospective observational memory clinic study.Scientific reports · 2025Observational
- Lumbar puncture seems to be safe and practical ın oldest-old patients: a protocol from a memory center.European geriatric medicine · 2025Article
- Correlation of Amine Concentrations in Blood and Cerebrospinal Fluid in Healthy Volunteers and Migraineurs.International journal of molecular sciences · 2025Article
- Incidence and Risk Factors of Post-Lumbar Puncture Headache in Patients With Cognitive Impairment.Brain and behavior · 2025Article
- Considerations for repetitive intrathecal procedures in long-term nusinersen treatment for non-ambulatory spinal muscular atrophy.Scientific reports · 2025Article
- The proof is in the pudding: patient engagement in studying cannabidiol in mild cognitive impairment.BMC complementary medicine and therapies · 2025Article
- Procedural and patient-related factors play differential roles in postdural puncture headache.Turkish journal of medical sciences · 2025Observational
- Exploring ethical considerations in medical research: Harnessing pre-generated transformers for AI-powered ethics discussions.PloS one · 2025Article
- Fluid biomarkers in multiple sclerosis: from current to future applications.The Lancet regional health. Europe · 2024Review
- Lumbar Puncture Complications: A Review of Current Literature.Current pain and headache reports · 2024Review
- Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Observational
- Preoperative examination and intraoperative cerebrospinal fluid leakage test for minimally invasive surgery of spinal extradural arachnoid cysts: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- A controlled lumbar puncture procedure improves the safety of lumbar puncture.Frontiers in neuroscience · 2023Article
- Successful epidural fibrin glue patch to treat intracranial hypotension in a patient with bacteraemia and malignancy.BJA open · 2022Article
- Lumbar puncture safety and tolerability in premanifest and manifest Huntington's disease: a multi-analysis cross-sectional study.Scientific reports · 2022Article
- Bedside colorimetric reagent dipstick in the diagnosis of meningitis in low- and middle-income countries: A prospective, international blinded comparison with laboratory analysis.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2022Article
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Authors and funding
22 authors at 13 institutions in 5 countries.
Funding
Abstract
importanceThis study assesses factors associated with the most common adverse event following lumbar puncture.
objectiveTo identify factors associated with the risk, onset, and persistence of post-dural puncture headache (PDPH). DESIGN, SETTING, AND
participantsWe performed univariate and multivariable analyses of 338 lumbar punctures in the Dominantly Inherited Alzheimer Network observational study using linear mixed models, adjusting for participant-level and family-level random effects. MAIN OUTCOMES AND MEASURES: We directly evaluated associations of 3 post-lumbar puncture outcomes (immediate postprocedural headache, PDPH at 24-hour follow-up, and PDPH receiving a therapeutic blood patch) with participant age and sex, positioning, collection method, needle size, needle insertion site, and cerebrospinal fluid (CSF) volume collected.
resultsThe incidence of adverse events included 73 immediate postprocedural headaches (21.6%), 59 PDPHs at 24-hour follow-up (17.5%), and 15 PDPHs receiving a therapeutic blood patch (4.4%). Greater volume of CSF collected was associated with increased risk of immediate postprocedural headache, largely owing to a nonlinear increase in risk on collection of volumes above 30 mL (odds ratio, 3.73 for >30 mL and 0.98 for <17 mL). In contrast, collection of higher volumes showed a protective effect in decreasing rates of PDPH at 24-hour follow-up and rates of PDPH receiving a therapeutic blood patch (odds ratio, 0.35 per 10 mL). Although differences in needle size did not reach statistical significance, no participant in the 24G needle group received a therapeutic blood patch compared to 8 of 253 for the larger 22G needles. CONCLUSIONS AND RELEVANCE: Factors that acutely lower CSF pressure (eg, seated positioning or extracting very high volumes of CSF) may be associated with transient post-lumbar puncture headache, without increasing rates of persistent PDPH or therapeutic blood patch. Collection of up to 30 mL of CSF appears to be well tolerated and safe.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.