Evidence map›Paper›PMID 25622090›Full record

ArticleNature chemical biology2015

Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases.

Jannik Bruun Larsen, Martin Borch Jensen, Vikram K Bhatia, Søren L Pedersen, Thomas Bjørnholm, Lars Iversen, Mark Uline, Igal Szleifer, Knud J Jensen, Nikos S Hatzakis and 1 more

Abstract read
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In one paragraph

Article in Nature chemical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Article
  2. Review
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  6. Article
  7. Review
  8. Caveolin assemblies displace one bilayer leaflet to organize and bend membranes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  11. Review
  12. Review
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  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jannik Bruun Larsen1] Bio-Nanotechnology and Nanomedicine Laboratory, Nano-Science Center, University of Copenhagen, Denmark. [2] Department of Chemistry, University of Copenhagen, Denmark. [3] Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, Denmark.
Martin Borch Jensen1] Bio-Nanotechnology and Nanomedicine Laboratory, Nano-Science Center, University of Copenhagen, Denmark. [2] Department of Chemistry, University of Copenhagen, Denmark. [3] Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, Denmark.
Vikram K Bhatia1] Bio-Nanotechnology and Nanomedicine Laboratory, Nano-Science Center, University of Copenhagen, Denmark. [2] Department of Chemistry, University of Copenhagen, Denmark. [3] Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, Denmark.
Søren L Pedersen1] Department of Chemistry, University of Copenhagen, Denmark. [2] Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, Denmark.
Thomas BjørnholmBio-Nanotechnology and Nanomedicine Laboratory, Nano-Science Center, University of Copenhagen, Denmark.
Lars Iversen1] Bio-Nanotechnology and Nanomedicine Laboratory, Nano-Science Center, University of Copenhagen, Denmark. [2] Department of Chemistry, University of Copenhagen, Denmark. [3] Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, Denmark.
Mark UlineDepartment of Chemical Engineering, University of South Carolina, Columbia, South Carolina, USA.
Igal SzleiferDepartment of Biomedical Engineering, Department of Chemistry and Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, USA.
Knud J Jensen1] Department of Chemistry, University of Copenhagen, Denmark. [2] Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, Denmark.
Nikos S Hatzakis1] Bio-Nanotechnology and Nanomedicine Laboratory, Nano-Science Center, University of Copenhagen, Denmark. [2] Department of Chemistry, University of Copenhagen, Denmark. [3] Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, Denmark.
Dimitrios Stamou1] Bio-Nanotechnology and Nanomedicine Laboratory, Nano-Science Center, University of Copenhagen, Denmark. [2] Department of Chemistry, University of Copenhagen, Denmark. [3] Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general.

Indexed as

Lipid BilayersLiposomesMembrane LipidsMembrane MicrodomainsMembranesMonomeric GTP-Binding ProteinsPalmitic AcidPhosphatidylcholines1,2-oleoylphosphatidylcholineLipid BilayersLiposomesMembrane LipidsMonomeric GTP-Binding ProteinsPalmitic AcidPhosphatidylcholines

Identifiers

PMID25622090

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.