ArticleNature materials2015
Calcium carbonate nucleation driven by ion binding in a biomimetic matrix revealed by in situ electron microscopy.
Article in Nature materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 430 citations in OpenAlex.
- In situ ptychographic x-ray nanotomography of temperature-controlled crystallization processes.Nature communications · 2026Article
- Additive-specific modulation of non-classical nucleation pathways.Nature communications · 2026Article
- Thermodynamics of calcium binding to heparin: Implications of solvation and water structuring for polysaccharide biofunctions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Scientific rationale and guidelines to use cane sugar as a performance enhancer in lime mortars.Scientific reports · 2025Article
- A nonclassical pathway of β-hematin crystal nucleation enables its suppression by antimalarials.Communications chemistry · 2025Article
- Effect of substrate mineralogy, biofilm and extracellular polymeric substances on bacterially induced carbonate mineralisation investigated with in situ nanoscale ToF-SIMS.Scientific reports · 2025Article
- Design Principles Of Inorganic-Protein Hybrid Materials for Biomedicine.Exploration (Beijing, China) · 2025Review
- Real-time visualisation of fast nanoscale processes during liquid reagent mixing by liquid cell transmission electron microscopy.Communications chemistry · 2025Article
- Exploring Biomineralization Processes Using In Situ Liquid Transmission Electron Microscopy: A Review.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Article
- Kinetics of Calcite Nucleation onto Sulfated Chitosan Derivatives and Implications for Water-Polysaccharide Interactions during Crystallization of Sparingly Soluble Salts.Crystal growth & design · 2024Article
- Study on Carbonation of Porcine Blood Hydrogel in the Composite Mortar of Ancient Chinese Architectural Painting.Gels (Basel, Switzerland) · 2024Article
- Myriad Mapping of nanoscale minerals reveals calcium carbonate hemihydrate in forming nacre and coral biominerals.Nature communications · 2024Article
- Intrafibrillar mineralization of type I collagen with calcium carbonate and strontium carbonate induced by polyelectrolyte-cation complexes.Nanoscale advances · 2024Article
- Universality of Hair as a Nucleant: Exploring the Effects of Surface Chemistry and Topography.Crystal growth & design · 2023Article
- Unlocking the mysterious polytypic features within vaterite CaCONature communications · 2023Article
- Article
- Insights into the precipitation kinetics of CaCOJournal of applied crystallography · 2023Article
- Assessing an aqueous flow cell designed for in situ crystal growth under X-ray nanotomography and effects of radiolysis products.Journal of synchrotron radiation · 2023Article
- Shape-Controlled Synthesis of Platinum-Based Nanocrystals and Their Electrocatalytic Applications in Fuel Cells.Nano-micro letters · 2023Review
17 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characteristic shapes, structures and properties of biominerals arise from their interplay with a macromolecular matrix. The developing mineral interacts with acidic macromolecules, which are either dissolved in the crystallization medium or associated with insoluble matrix polymers, that affect growth habits and phase selection or completely inhibit precipitation in solution. Yet little is known about the role of matrix-immobilized acidic macromolecules in directing mineralization. Here, by using in situ liquid-phase electron microscopy to visualize the nucleation and growth of CaCO3 in a matrix of polystyrene sulphonate (PSS), we show that the binding of calcium ions to form Ca-PSS globules is a key step in the formation of metastable amorphous calcium carbonate (ACC), an important precursor phase in many biomineralization systems. Our findings demonstrate that ion binding can play a significant role in directing nucleation, independently of any control over the free-energy barrier to nucleation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.