Evidence map›Paper›PMID 25621950›Full record

ArticleNature cell biology2015

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis.

Miranda Y Fong, Weiying Zhou, Liang Liu, Aileen Y Alontaga, Manasa Chandra, Jonathan Ashby, Amy Chow, Sean Timothy Francis O'Connor, Shasha Li, Andrew R Chin and 15 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05587088 (Evaluation of the Safety and Efficacy of Esperanza Extract), which is not on this map. Cited by 738 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
738citing papers in PubMed, 3 pooled it
32.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05587088 phase1 / phase2unknown statusnot on this mapstarted 2022, after this paper: background citation

Evaluation of the Safety and Efficacy of Esperanza Extract (Petiveria Alliacea) in Patients With Metastatic Gastrointestinal Tumors and Acute Leukemia

TypeinterventionalSponsorHospital Universitario San IgnacioRan2022 to 2023Enrolled82ConditionsNeoplasm, Stomach, Gastric Neoplasms Malignant, Pancreatic Neoplasms, Colorectal NeoplasmsArmsPetiveria Alliacea Preparation, Placebo
3 · Its place in the literature

Who cites it

738 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,097 citations in OpenAlex.

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  7. Niches in cancer: from primary tumors to metastatic disease.Journal of hematology & oncology · 2026
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678 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 5 institutions in 2 countries.

Miranda Y FongDepartment of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA.
Weiying ZhouDepartment of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA.
Liang Liu1] Department of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA [2] Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Aileen Y AlontagaDepartment of Molecular Medicine, City of Hope Beckman Research Institute, Duarte, California 91010, USA.
Manasa Chandra1] Department of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA [2] City of Hope Irell &Manella Graduate School of Biological Sciences, Duarte, California 91010, USA.
Jonathan AshbyDepartment of Chemistry, University of California, Riverside, California 92521, USA.
Amy ChowDepartment of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA.
Sean Timothy Francis O'ConnorDepartment of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA.
Shasha LiDepartment of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA.
Andrew R Chin1] Department of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA [2] City of Hope Irell &Manella Graduate School of Biological Sciences, Duarte, California 91010, USA.
George SomloDepartment of Medical Oncology, City of Hope Medical Center, Duarte, California 91010, USA.
Melanie Palomares1] Department of Medical Oncology, City of Hope Medical Center, Duarte, California 91010, USA [2] Department of Population Sciences, City of Hope Beckman Research Institute, Duarte, California 91010, USA.
Zhuo LiCore of Electron Microscopy, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA.
Jacob R Tremblay1] Department of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA [2] City of Hope Irell &Manella Graduate School of Biological Sciences, Duarte, California 91010, USA.
Akihiro TsuyadaDepartment of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA.
Guoqiang SunDepartment of Neurosciences, City of Hope Beckman Research Institute, Duarte, California 91010, USA.
Michael A ReidDepartment of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA.
Xiwei WuCore of Integrative Genomics, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA.
Piotr SwiderskiCore of Synthetic and Biopolymer Chemistry, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA.
Xiubao RenDepartment of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Yanhong ShiDepartment of Neurosciences, City of Hope Beckman Research Institute, Duarte, California 91010, USA.
Mei KongDepartment of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA.
Wenwan ZhongDepartment of Chemistry, University of California, Riverside, California 92521, USA.
Yuan ChenDepartment of Molecular Medicine, City of Hope Beckman Research Institute, Duarte, California 91010, USA.
Shizhen Emily Wang1] Department of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA [2] Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
City of Hope · USBeckman Research InstituteCity Of Hope National Medical Center · USTianjin Medical University Cancer Institute and Hospital · CNUniversity of California, Riverside · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
SUMO modification and DNA damage response in cancer therapyR01GM086171 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, YUAN · 2008 to 2020
$5.2M
Cancer Cell Adaption to Glutamine DeprivationR01CA183989 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KONG, MEI · 2014 to 2019
$1.7M
SENP:Conformational Dynamics and Inhibition by Small MoleculesR01GM102538 · NIGMS · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, YUAN · 2012 to 2015
$1.7M
Mechanism of chemoresistance mediated by TGF-betaR01CA163586 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, SHIZHEN EMILY · 2012 to 2016
$1.7M
Role of miR-105 in breast cancer metastasisR01CA166020 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, SHIZHEN EMILY · 2012 to 2016
$1.7M
NCI NIH HHS P30 CA033572NCI NIH HHS P30CA33572NCI NIH HHS R01 CA163586NCI NIH HHS R01CA163586NCI NIH HHS R01 CA166020NCI NIH HHS R01CA166020NIGMS NIH HHS R01 GM086171NIGMS NIH HHS R01 GM102538
6 · The paper itself

Abstract

Reprogrammed glucose metabolism as a result of increased glycolysis and glucose uptake is a hallmark of cancer. Here we show that cancer cells can suppress glucose uptake by non-tumour cells in the premetastatic niche, by secreting vesicles that carry high levels of the miR-122 microRNA. High miR-122 levels in the circulation have been associated with metastasis in breast cancer patients, and we show that cancer-cell-secreted miR-122 facilitates metastasis by increasing nutrient availability in the premetastatic niche. Mechanistically, cancer-cell-derived miR-122 suppresses glucose uptake by niche cells in vitro and in vivo by downregulating the glycolytic enzyme pyruvate kinase. In vivo inhibition of miR-122 restores glucose uptake in distant organs, including brain and lungs, and decreases the incidence of metastasis. These results demonstrate that, by modifying glucose utilization by recipient premetastatic niche cells, cancer-derived extracellular miR-122 is able to reprogram systemic energy metabolism to facilitate disease progression.

Indexed as

AstrocytesBase SequenceBreast NeoplasmsBromodeoxyuridineCell Line, TumorCell ProliferationDown-RegulationExosomesFemaleFibroblastsGlucoseHumansLuciferasesLungMicroRNAsMolecular Sequence DataBromodeoxyuridineGlucoseLuciferasesMicroRNAsMIRN122 microRNA, humanPyruvate Kinase

Identifiers

PMID25621950
PMCPMC4380143
OpenAlexW1975355918

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.