SynthesisPloS one2015
Challenges of improving the evidence base in smaller surgical specialties, as highlighted by a systematic review of gastroschisis management.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Safety and usefulness of plastic closure in infants with gastroschisis: a systematic review and meta-analysis.Pediatric surgery international · 2019Pooled it
- A systematic review of the quality of conduct and reporting of systematic reviews and meta-analyses in paediatric surgery.PloS one · 2017Pooled it
- Variability of outcome reporting in Hirschsprung's Disease and gastroschisis: a systematic review.Scientific reports · 2016Pooled it
- What Evidence Underlies Clinical Practice in Paediatric Surgery? A Systematic Review Assessing Choice of Study Design.PloS one · 2016Pooled it
- Indication for delivery and neonatal outcomes in prenatally diagnosed gastroschisis: A 20-year retrospective cohort study.Pregnancy (Hoboken, N.J.) · 2026Article
- Defining treatment success in children with surgical conditions.Archives of disease in childhood · 2024Article
- Developing a core outcome set for the health outcomes for children and adults with congenital oesophageal atresia and/or tracheo-oesophageal fistula: OCELOT task group study protocol.BMJ paediatrics open · 2024Article
- Case Report: foetal gastroschisis with ideal pregnancy outcomes under multidisciplinary treatment management.Frontiers in pediatrics · 2024Article
- Variation in hospital costs for gastroschisis closure techniques.American journal of surgery · 2020Article
- Sutureless Approach for Gastroschisis Patients in Palestine.Case reports in surgery · 2020Article
- Development of a gastroschisis core outcome set.Archives of disease in childhood. Fetal and neonatal edition · 2019Article
- Article
- Race and outcomes in gastroschisis repair: a nationwide analysis.Journal of pediatric surgery · 2017Article
- Development of a core outcome set for use in determining the overall success of gastroschisis treatment.Trials · 2016Review
- Novel multidisciplinary approach to monitor and treat fetuses with gastroschisis using the Svetliza Reducibility Index and the EXIT-like procedure.Einstein (Sao Paulo, Brazil)Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo identify methods of improving the evidence base in smaller surgical specialties, using a systematic review of gastroschisis management as an example.
backgroundOperative primary fascial closure (OPFC), and silo placement with staged reduction and delayed closure (SR) are the most commonly used methods of gastroschisis closure. Relative merits of each are unclear.
methodsA systematic review and meta-analysis was performed comparing outcomes following OPFC and SR in infants with simple gastroschisis. Primary outcomes of interest were mortality, length of hospitalization and time to full enteral feeding.
results751 unique articles were identified. Eight met the inclusion criteria. None were randomized controlled trials. 488 infants underwent OPFC and 316 underwent SR. Multiple studies were excluded because they included heterogeneous populations and mixed intervention groups. Length of stay was significantly longer in the SR group (mean difference 8.97 days, 95% CI 2.14-15.80 days), as was number of post-operative days to complete enteral feeding (mean difference 7.19 days, 95%CI 2.01-12.36 days). Mortality was not statistically significantly different, although the odds of death were raised in the SR group (OR 1.96, 95%CI 0.71-5.35).
conclusionsDespite showing some benefit of OPFC over SR, our results are tempered by the low quality of the available studies, which were small and variably reported. Coordinating research through a National Paediatric Surgical Trials Unit could alleviate many of these problems. A similar national approach could be used in other smaller surgical specialties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.