Evidence map›Paper›PMID 25621562›Full record

ReviewCurrent opinion in pulmonary medicine2015

Asbestosis and environmental causes of usual interstitial pneumonia.

Mridu Gulati, Carrie A Redlich

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in pulmonary medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Fibrotic interstitial lung diseases and air pollution: a systematic literature review.European respiratory review : an official journal of the European Respiratory Society · 2020
    Pooled it
  4. Pooled it
  5. Review
  6. Multi-omics insights into the mechanisms and prognosis of IPF.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2026
    Review
  7. Hermansky-Pudlak Syndrome Pulmonary Fibrosis: Monogenic Disorder, Multi-Omics Discovery.American journal of respiratory cell and molecular biology · 2026
    Article
  8. Article
  9. The Role of Particle Inhalation in Idiopathic Pulmonary Fibrosis.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Asbestos Exposure and Severity of COVID-19.International journal of environmental research and public health · 2022
    Article
  16. Lung Fibrosis Finds an Unsung Hero in Neuropeptide Y.American journal of respiratory cell and molecular biology · 2022
    Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mridu GulatiSection of Pulmonary, Critical Care and Sleep Medicine, and Yale Occupational and Environmental Medicine Program, Yale School of Medicine, New Haven, Connecticut, USA.
Carrie A Redlich
Yale University · US

Funding

Novel Immunologic Effects of Semaphorin 7a in IPFR01HL109233 · NHLBI · YALE UNIVERSITY · PI HERZOG, ERICA L · 2011 to 2019
$3.7M
Significance Circulating Semaphorin 7a+ve Cells in Pulmonary SarcoidosisU01HL112702 · NHLBI · YALE UNIVERSITY · PI HERZOG, ERICA L · 2012 to 2014
$488k
Longitudinal Study of Respiratory Function in Aluminum Smelter WorkersK01OH008644 · OH · YALE UNIVERSITY · PI GULATI, MRIDU · 2006 to 2008
$292k
NHLBI NIH HHS R01 HL109233NHLBI NIH HHS U01 HL112702NIOSH CDC HHS K01 OH008644
6 · The paper itself

Abstract

purpose of reviewRecent epidemiologic investigations suggest that occupational and environmental exposures contribute to the overall burden of idiopathic pulmonary fibrosis (IPF). This article explores the epidemiologic and clinical challenges to establishing exposure associations, the current literature regarding exposure disease relationships and the diagnostic work-up of IPF and asbestosis patients. RECENT

findingsIPF patients demonstrate a histopathologic pattern of usual interstitial pneumonia. In the absence of a known cause or association, a usual interstitial pneumonia pattern leads to an IPF diagnosis, which is a progressive and often terminal fibrotic lung disease. It has long been recognized that asbestos exposure can cause pathologic and radiographic changes indistinguishable from IPF. Several epidemiologic studies, primarily case control in design, have found that a number of other exposures that can increase risk of developing IPF include cigarette smoke, wood dust, metal dust, sand/silica and agricultural exposures. Lung mineralogic analyses have provided additional support to causal associations. Genetic variation may explain differences in disease susceptibility among the population. SUMMARY: An accumulating body of literature suggests that occupational and environmental exposure can contribute to the development of IPF. The impact of exposure on the pathogenesis and clinical course of disease requires further study.

Indexed as

Environmental ExposureAsbestosAsbestosisHumansLung Diseases, InterstitialOccupational DiseasesRisk FactorsAsbestos

Identifiers

PMID25621562
PMCPMC4472384
OpenAlexW1990285594

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.