ArticleFrontiers in cellular and infection microbiology2014
Whole genome sequencing and analysis reveal insights into the genetic structure, diversity and evolutionary relatedness of luxI and luxR homologs in bacteria belonging to the Sphingomonadaceae family.
Article in Frontiers in cellular and infection microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 45 citations in OpenAlex.
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- Insights into Adaptive Mechanisms of Extreme Acidophiles Based on Quorum Sensing/Quenching-Related Proteins.mSystems · 2022Article
- Genomic characterization of bacteria from the ultra-oligotrophic Madison aquifer: insight into the archetypical LuxI/LuxR and identification of novel LuxR solos.BMC research notes · 2021Article
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- Antibiotic resistance: bioinformatics-based understanding as a functional strategy for drug design.RSC advances · 2020Review
- The complete genome sequence of the algicidal bacteriumBiotechnology reports (Amsterdam, Netherlands) · 2020Article
- Insight into the resistome and quorum sensing system of a divergentAccess microbiology · 2020Article
- Draft Genome Sequences of FiveMicrobiology resource announcements · 2019Article
- Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria.Nature microbiology · 2019Article
- Nutrient removal and microalgal biomass production from different anaerobic digestion effluents with Chlorella species.Scientific reports · 2019Article
- Insight Into the Microbial Co-occurrence and Diversity of 73 Grapevine (Frontiers in microbiology · 2019Article
- Improved genome ofPeerJ · 2019Article
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- Transcriptome Analysis ofInternational journal of molecular sciences · 2018Article
- Evolutionary Genomics of an Ancient Prophage of the Order Sphingomonadales.Genome biology and evolution · 2017Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Here we report the draft genomes and annotation of four N-acyl homoserine lactone (AHL)-producing members from the family Sphingomonadaceae. Comparative genomic analyses of 62 Sphingomonadaceae genomes were performed to gain insights into the distribution of the canonical luxI/R-type quorum sensing (QS) network within this family. Forty genomes contained at least one luxR homolog while the genome of Sphingobium yanoikuyae B1 contained seven Open Reading Frames (ORFs) that have significant homology to that of luxR. Thirty-three genomes contained at least one luxI homolog while the genomes of Sphingobium sp. SYK6, Sphingobium japonicum, and Sphingobium lactosutens contained four luxI. Using phylogenetic analysis, the sphingomonad LuxR homologs formed five distinct clades with two minor clades located near the plant associated bacteria (PAB) LuxR solo clade. This work for the first time shows that 13 Sphingobium and one Sphingomonas genome(s) contain three convergently oriented genes composed of two tandem luxR genes proximal to one luxI (luxR-luxR-luxI). Interestingly, luxI solos were identified in two Sphingobium species and may represent species that contribute to AHL-based QS system by contributing AHL molecules but are unable to perceive AHLs as signals. This work provides the most comprehensive description of the luxI/R circuitry and genome-based taxonomical description of the available sphingomonad genomes to date indicating that the presence of luxR solos and luxI solos are not an uncommon feature in members of the Sphingomonadaceae family.
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