ArticleFrontiers in cellular and infection microbiology2014
Mathematical modeling provides kinetic details of the human immune response to vaccination.
Article in Frontiers in cellular and infection microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
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- Characterizing population-level short-term waning of newcastle disease humoral immunity of MDA-positive broiler chicks with day-old HB1 vaccination in Nigeria.Veterinary and animal science · 2026Article
- BCG vaccination reduces the rate of Mycobacterium tuberculosis dissemination between murine lungs.Research square · 2026Article
- BCG vaccination reduces the rate of Mycobacterium tuberculosis dissemination between murine lungs.bioRxiv : the preprint server for biology · 2026Article
- Quantitative systems pharmacology model of B cell immune response in mouse.Frontiers in immunology · 2026Article
- Quantification of the IgG antibody response half-life for hybrid immunity to SARS-CoV-2.BMC medicine · 2025Article
- Emergence of SARS-CoV-2 Omicron lineages shifted antibody-mediated protection curves.iScience · 2025Article
- Immunostimulatory/Immunodynamic model of mRNA-1273 to guide pediatric vaccine dose selection.CPT: pharmacometrics & systems pharmacology · 2025Article
- Appropriate Sampling and Longer Follow-Up Are Required to Rigorously Evaluate Longevity of Humoral Memory After Vaccination.ImmunoHorizons · 2024Article
- Opening Pandora's box: caveats with using toolbox-based approaches in mathematical modeling in biology.Frontiers in applied mathematics and statistics · 2024Article
- serosim: An R package for simulating serological data arising from vaccination, epidemiological and antibody kinetics processes.PLoS computational biology · 2023Article
- Appropriate sampling and long follow-up are required to rigorously evaluate longevity of humoral memory after Vaccination.medRxiv : the preprint server for health sciences · 2023Article
- Estimating immunity with mathematical models for SARS-CoV-2 after COVID-19 vaccination.NPJ vaccines · 2023Article
- Article
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- Multiple Treatment Cycles of Neural Stem Cell Delivered Oncolytic Adenovirus for the Treatment of Glioblastoma.Cancers · 2021Article
- Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity.eLife · 2021Article
- Review
- Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals.BMC bioinformatics · 2020Article
- Treatment timing shifts the benefits of short and long antibiotic treatment over infection.Evolution, medicine, and public health · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With major advances in experimental techniques to track antigen-specific immune responses many basic questions on the kinetics of virus-specific immunity in humans remain unanswered. To gain insights into kinetics of T and B cell responses in human volunteers we combined mathematical models and experimental data from recent studies employing vaccines against yellow fever and smallpox. Yellow fever virus-specific CD8 T cell population expanded slowly with the average doubling time of 2 days peaking 2.5 weeks post immunization. Interestingly, we found that the peak of the yellow fever-specific CD8 T cell response was determined by the rate of T cell proliferation and not by the precursor frequency of antigen-specific cells as has been suggested in several studies in mice. We also found that while the frequency of virus-specific T cells increased slowly, the slow increase could still accurately explain clearance of yellow fever virus in the blood. Our additional mathematical model described well the kinetics of virus-specific antibody-secreting cell and antibody response to vaccinia virus in vaccinated individuals suggesting that most of antibodies in 3 months post immunization were derived from the population of circulating antibody-secreting cells. Taken together, our analysis provided novel insights into mechanisms by which live vaccines induce immunity to viral infections and highlighted challenges of applying methods of mathematical modeling to the current, state-of-the-art yet limited immunological data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.